2013 Fiscal Year Final Research Report
Biological activity of IL-5Ra variants and their roles for eosinophilic differentiation
| Project/Area Number |
23791098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 好酸球 / IL-5 / 分化 |
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| Research Abstract |
IL-5 is a cytokine that is necessary for differentiation and maturation for eosinophils from their precursor cells such as hematopoietic stem cells. IL-5 also plays activation and survival for mature eosinophils. This study showed two novel IL-5Ras, namely IL-5Ra V7 and V8, and constructed the expression systems for I-5Ra V7 and V8 on mammalian cells using retorovirus.
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