2012 Fiscal Year Final Research Report
An investigation of a contribution of toll-like receptor signalinginhibitory molecules to connective tissue diseases
| Project/Area Number |
23791101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAWASAKI Aya 筑波大学, 医学医療系, 研究員 (30532816)
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| Research Collaborator |
TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 全身性エリテマトーデス / 疾患感受性遺伝子 / TLR / LILR / LAIR / PRDM1 / 多型 |
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| Research Abstract |
We examined whether genes encoding TLR7 and TLR9 signaling inhibitory molecules and related molecule, LILRA4, LAIR1 and IRF4 and PRDM1 are involved in the susceptibility to systemic lupus erythematosus (SLE). We detected the association of 4 SNPs in LILRA4-LAIR1. On the other hand, no evidence for association of IRF4 was observed. We also detected an association of PRDM1 with SLE with nephropathy.
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[Journal Article] Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population2012
Author(s)
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
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Journal Title
Lupus
Volume: Vol.21
Pages: 890-895
DOI
Peer Reviewed
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