2013 Fiscal Year Final Research Report
Investigation on the role of microbiota and regulatory T cells on allregic airway inflammation
| Project/Area Number |
23791104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HARADA Hiroaki 東京大学, 医学部附属病院, 助教 (40579687)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アレルギー学 |
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| Research Abstract |
We could not prove the hypothesis that microbiota could induce regulatory T cells and suppress allergic airway inflammation. Transcription factor Blimp-1 is thought to be implicated in the regulatory function of LAG3+Tregs, which is recently proposed as a novel regulatory T cell subcet. We showed that Blimp-1 expression of T cells enhanced eosiophil infiltration and suppressed lymphocyte infiltration and collagen deposition in mice with allergic airway inflammation. Our study indicates that LA3+Tregs are involved in the pathogenesis of allergic airway inflammation.
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