2012 Fiscal Year Final Research Report
The novel antigen-specific immune regulation for pathogenic CD8+ T cells
| Project/Area Number |
23791109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIRATA Shinya 熊本大学, 大学院・生命科学研究部, 助教 (60418829)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 臨床免疫学 / 筋炎 |
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| Research Abstract |
It is desirable to develop a therapeutic means to down-modulate immune responses in anantigen-specific manner without causing systemic immune suppression. We tried the immune regulationof pathogenic CD8+ T cells by mouse ES cell-derived dendritic cells (ES-DCs) expressing both antigenand immunosuppressive molecule, such as TRAIL or PD-L1. In this period, we brought in the C-proteininduced myositis, CIM, which was disease model caused by pathogenic CD8+ T cells. The functionalES-DCs expressing immunosuppressive molecule was prepared. These ES-DCs may prevent pathogenicCD8+ T cells-derived autoimmune disease.
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[Journal Article] Suppression of elevations in serum Creactive protein levels by anti-IL-6autoantibodies in two patients withsevere bacterial infections2013
Author(s)
Nanki, T., Onoue, I., Nagasaka, K.,Takayasu, A., Ebisawa, M., Hosoya, T.,Shirai, T., Sugihara, T., Hirata, S.,Kubota, T., Harigai, M. and Miyasaka, N
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Journal Title
Ann RheumDis
Volume: 72(6)
Pages: 1100-2
DOI
Peer Reviewed
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[Journal Article] Immunotherapy with pluripotent stemcell-derived dendritic cells2011
Author(s)
Senju, S., Matsunaga, Y., Fukushima, S.,Hirata, S., Motomura, Y., Fukuma, D.,Matsuyoshi, H. and Nishimura, Y
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Journal Title
SeminImmunopathol
Volume: 33(6)
Pages: 603-12
DOI
Peer Reviewed
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[Journal Article] Oligomannose-coatedliposomes efficiently induce humanT-cell leukemia virus-1-specificcytotoxic T lymphocytes withoutadjuvant2011
Author(s)
Kozako, T., Hirata, S., Shimizu, Y.,Satoh, Y., Yoshimitsu, M., White, Y.,Lemonnier, F., Shimeno, H., Soeda, S.and Arima, N
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Journal Title
FEBS J
Volume: 278(8)
Pages: 1358-66
DOI
Peer Reviewed
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[Journal Article] Identification ofHLA-A2-restricted CTL epitopes of anovel tumour-associated antigen, KIF20A,overexpressed in pancreatic cancer2011
Author(s)
Imai, K., Hirata, S., Irie, A., Senju,S., Ikuta, Y., Yokomine, K., Harao, M.,Inoue, M., Tomita, Y., Tsunoda, T.,Nakagawa. H., Nakamura, Y., Baba, H. andNishimura, Y
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Journal Title
BrJ Cancer
Volume: 104(2)
Pages: 300-7
DOI
Peer Reviewed
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[Journal Article] Peptides derived fromhuman insulin-like growth factor-IImRNA binding protein 3 can induce humanleukocyte antigen-A2-restricted cytotoxic T lymphocytes reactive tocancer cells2011
Author(s)
Tomita, Y., Harao, M., Senju, S., Imai,K., Hirata, S., Irie, A., Inoue, M.,Hayashida, Y., Yoshimoto, K., Shiraishi,K., Mori, T., Nomori, H., Kohrogi, H.,and Nishimura Y
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Journal Title
Cancer Sci
Volume: 102(1)
Pages: 71-8
DOI
Peer Reviewed
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