2012 Fiscal Year Final Research Report
Role of GM-CSF secreting CD4 T cells in rheumatoid arthritis and its animal model
| Project/Area Number |
23791113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 関節リウマチ / 関節リウマチ / CD4T 細胞 / GM-CSF / fibroblast-like synoviocyte |
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| Research Abstract |
To study the role of GM-CSF secreting CD4 T cells in rheumatoid arthritis, we conducted co-culture experiments of human lymphocytes and animal experiments. By co-culture experiments, we identified a molecule expressed on fibroblast-like synoviocyte (FLS) which drives the production of GM-CSF from naive CD4 T cells. By animal experiments, we found that GM-CSF produced by CD4 T cells at the site of inflammation promoted inflammation by enhancing the production of IL-6, IL-1 and TNF from macrophages.
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