2012 Fiscal Year Final Research Report
To study the mechanism by which endothelial cell derived IL-33 contributes to the development of vasculitis
| Project/Area Number |
23791126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | IL-33 / mast cell / vasculitis / apoptosis |
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| Research Abstract |
The levels of Interleukin (IL)-33 were not elevated in the serum obtained from patients with vasculitis including ANCA-associated vasculitis. The regulation of MC survival by cytokines such as IL-3, SCF, IL4, and IL-10 have been demonstrated in prior studies. Given the newly found importance of IL-33 in MC immune functions, including cytokine production and granule maturation, we examined its effect on MC survival. We analyzed the effects of IL-33 on MC proliferation, survival and apoptosis. We have demonstrated that IL-33 prevents apoptosis of mouse bone marrow derived MCs (mBMMCs) induced by growth factor deprivation in vitro. This effect could represent a new mechanism by which IL-33 producing cells, such as fibroblasts, support the maintenanceof tissue mastocytosis.
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[Journal Article] Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus.2012
Author(s)
Kaieda S, Kobayashi T, Moroki M, Honda S, Yuge K, Kawano H, Mitsuyama K, Sata M, Ida H, Hoshino T, Fukuda T.
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Journal Title
Peer Reviewed
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