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2013 Fiscal Year Final Research Report

Improvement of serological diagnosis of leptospirosis and its epidemiological dynamics

Research Project

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Project/Area Number 23791130
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionOsaka City University (2012-2013)
Hokkaido University (2011)

Principal Investigator

RIE ISOZUMI  大阪市立大学, 医学(系)研究科(研究院), 講師 (30550355)

Research Collaborator ARIKAWA Jiro  北海道大学, 大学院医学研究科, 教授 (10142704)
YOSHIMATSU Kumiko  北海道大学, 大学院医学研究科, 准教授 (90220722)
SHIMIZU Kenta  北海道大学, 大学院医学研究科, 助教 (20466840)
Project Period (FY) 2011 – 2013
Keywordsレプトスピラ症 / 血清学的診断 / ELISA / 疫学動態 / 熱帯地域
Research Abstract

Leptospirosis is wide spread disease especially in tropical developing countries, which cause symptom in human often severe to lethal. Early diagnosis and early treatment is quite important to avoid bad outcome, but it is difficult to diagnose at early stage of disease by current diagnose methods whose sensitivity and specificity are also insufficient to do complete diagnosis. With the diagnostic problem, we do not understand accurate epidemic status of leptospirosis in tropical developing countries. In this study, we developed a new diagnostic method based on ELISA with recombinant antigens (LipL32 and LigA). We tested samples from epidemic area (Thailand, Sri Lanka and Vietnam) with this method. We also investigated wild rats in Hanoi which are important vector of leptospirosis.

  • Research Products

    (8 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island2014

    • Author(s)
      Kaneko, A.; Chaves, L. F.; Taleo, G.; Kalkoa, M.; Isozumi, R.; Wickremasinghe, R.; Perlmann, H.; Takeo, S.; Tsuboi, T.; Tachibana, S.; Kimura, M.; Bjorkman, A.; Troye-Blomberg, M.; Tanabe, K.; Drakeley, C.
    • Journal Title

      Vanuatu. Infect Immun

      Volume: 82(1) Pages: 243-52

    • Peer Reviewed
  • [Journal Article] A survey of rodent-borne pathogens carried by wild Rattus spp. in Northern Vietnam2013

    • Author(s)
      Koma, T.; Yoshimatsu, K.; Yasuda, S. P.; Li, T.; Amada, T.; Shimizu, K.; Isozumi, R.; Mai, L. T.; Hoa, N. T.; Nguyen, V.; Yamashiro, T.; Hasebe, F.; Arikawa, J.
    • Journal Title

      Epidemiol Infect

      Volume: 141(9) Pages: 1876-84

    • Peer Reviewed
  • [Journal Article] Cross-reactivity of secondary antibodies against African rodents and application for sero-surveillance2013

    • Author(s)
      Nakamura, I.; Hang'ombe, B. M.; Sawa, H.; Kobayashi, S.; Orba, Y.; Ishii, A.; Thomas, Y.; Isozumi, R.; Yoshimatsu, K.; Mweene, A. S.; Takada, A.; Sugimoto, C.; Arikawa, J.
    • Journal Title

      J Vet Med Sci

      Volume: 75(6) Pages: 819-25

    • Peer Reviewed
  • [Journal Article] from environment, Vietnam2012

    • Author(s)
      Isozumi, R.; Yoshimatsu, K.; Yamashiro, T.; Hasebe, F.; Nguyen, B. M.; Ngo, T. C.; Yasuda, S. P.; Koma, T.; Shimizu, K.; Arikawa, J.
    • Journal Title

      Emerg Infect Dis

      Volume: 18(8) Pages: 1383-5

    • Peer Reviewed
  • [Journal Article] Application of truncated nucleocapsid protein (N) for serotyping ELISA of murinae-associated hantavirus infection in rats2012

    • Author(s)
      Yasuda, S. P.; Yoshimatsu, K.; Koma, T.; Shimizu, K.; Endo, R.; Isozumi, R.; Arikawa, J.
    • Journal Title

      J Vet Med Sci

      Volume: 74(2) Pages: 215-9

    • Peer Reviewed
  • [Journal Article] Plasmodium falciparum : differential selection of drug resistance alleles in contiguous urban and per -urban areas of Brazzaville, Republic of Congo2011

    • Author(s)
      Tsumori, Y.; Ndounga, M.; Sunahara, T.; Hayashida, N.; Inoue, M.; Nakazawa, S.; Casimiro, P.; Isozumi, R.; Uemura, H.; Tanabe, K.; Kaneko, O.; Culleton, R.
    • Journal Title

      PLoS One

      Volume: 6(8) Pages: e23430

    • Peer Reviewed
  • [Presentation] スリランカ産Rattus rattusおよびBandicota bengalensisの系統学的位置2012

    • Author(s)
      安田俊平、Chandika D. Gamage、小泉信夫、西尾佐奈恵、五十棲理恵、清水健太、駒貴明、天田貴子、鈴木仁、吉松組子、有川二郎
    • Organizer
      日本哺乳類学会2012年度大会
    • Place of Presentation
      麻布大学(神奈川県)
    • Year and Date
      20120000
  • [Presentation] Seroprevalence of anti-leptospira antibodies among patients with acute febrile illness with renal dysfunction in spite of negative result with several leptospira tests in Thailand2011

    • Author(s)
      Rie Isozumi, Kumiko Yoshimatsu, Sirima Pattamadilok, Sanit Kumperasart, Jiro Arikawa
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-09

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Published: 2015-06-25   Modified: 2015-07-08  

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