Role of Innate immunity on the exacerbation of bronchial asthma via influenza virus infection

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791131
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Tohoku University
• Principal Investigator: AOYAGI Tetsuji 東北大学, 大学病院, 助教 (50581609)
• Project Period (FY): 2011 – 2012
• Keywords: インフルエンザウイルス / 気管支喘息 / 肺傷害 / 線維化 / エラスターゼ

Research Abstract

Influenza virus is the reason of acute exacerbation bronchial asthma. However, it was lack of understanding for this mechanism. First, we have utilized mouse models of bronchial asthma induced by ovalbumin to experimentally examine a possible aggregation between influenza virus and asthma. We could not find any difference of clinical outcome, accumulation of inflammatory cells and Th1/Th2 related cytokines between normal and asthma mouse after influenza virus infection. We, next, examined whether tissue remodeling was observed after severe inflammation by influenza virus infection. Mice were inoculated non-lethal dose of influenza virus, histopathological analysis presented bronchiectasis and peribronchial collagen diposition and collagen level in the lung was significantly elevated compared to normal mice at the day 35 post-infection. This model could be a novel experimental tool for approaching the pathogenic mechanism of bronchial remodeling after sever inflammation.

Research Products

• [Journal Article] Characteristics of infectious diseases in hospitalized patients during the early phase after the 2011 great East Japan earthquake : pneumonia as a significant reason for hospital care (2013)
  • Author(s): Aoyagi T, Yamada M, Kunishima H, Tokuda K, Yano H, Ishibashi N, Hatta M, Endo S, Arai K, Inomata S, Gu Y, Kanamori H, Kitagawa M, Hirakata Y, Kaku M
  • Journal Title: Chest Volume: 143(2) Pages: 349-56
  • DOI: 10.1378/chest.11-3298
  • Peer Reviewed
• [Journal Article] Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome (2013)
  • Author(s): Kudo D, Toyama M, Aoyagi T, Akahori Y, Yamamoto H, Ishii1 K, Kanno E, Maruyama R, Kaku M, Kushimoto S, Kawakami K
  • Journal Title: Clin Exp Immunol Volume: 173(2) Pages: 276-87
  • DOI: 10.1111/cei.12106
  • Peer Reviewed
• [Journal Article] Low-dose interferon-αtreatment improves survival and inflammatory responses in a mouse model of fulminant acute respiratory distress syndrome (2013)
  • Author(s): Kudo D, Uno K, Aoyagi T, Akahori Y, Ishii K, Kanno E, Maruyama R, Kushimoto S, Kaku M, Kawakami K
  • Journal Title: Inflammation Volume: 36(4) Pages: 812-20
  • DOI: 10.1007/s10753-013-9607-1
  • Peer Reviewed
• [Presentation] Association between psm-mec on the Mobile Genetic Element and Clinical Manifestation of Methicillin-Resistant Staphylococcus aureus Infection (2013)
  • Author(s): Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Endo S, Hatta M, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
  • Organizer: IDweek
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20131002-06
• [Presentation] 肺線維化をきたすインフルエンザウイルス感染肺障害モデルマウスの作成 (2013)
  • Author(s): 青柳哲史、川上和義、石井恵子、金森肇、遠藤史郎、八田益充、具芳明、徳田浩一、矢野寿一、國島広之、北川美穂、賀来満夫
  • Organizer: 第87回日本感染症学会学術講演会・第61回日本化学療法学会合同学会
  • Place of Presentation: 横浜
  • Year and Date: 20130605-06
• [Presentation] Lung fibrosis after acute lung injury caused by H1N1 influenza virus infection in mice (2013)
  • Author(s): Aoyagi T, Kawakami K, Ishii K, Endo S, Kanamori H, Gu Y, Hatta M, Tokuda K, Yano H, Kunishima H, Kaku M
  • Organizer: American Thoracic Society 2013
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20130517-22
• [Presentation] A novel ALI/ARDS experimental animal model caused by H1N1 influenza virus (2013)
  • Author(s): Aoyagi T, Kawakami K, Ishii K, Endo S, Kanamori H, Gu Y, Hatta M, Tokuda K, Yano H, Kunishima H, Kaku M
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130509-10
• [Presentation] 肺線維化を来たすインフルエンザウイルス誘発急性肺傷害モデルマウスの作成 (2013)
  • Author(s): 青柳哲史、川上和義、石井恵子、山田充啓、金森肇、國島広之、賀来満夫
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 20130419-21
• [Presentation] Candida albicans versus non-albicans Candida in general wards at the tertiary University hospital in Japan (2012)
  • Author(s): Aoyagi T, Kunishima H, Kanamori H, Endo S, Hatta M, Gu Y, Yamada M, Tokuda K, Yano H, Kitagawa M, Kaku M
  • Organizer: 8th International Healthcare Infection Society (HIS) Conference and Federation of Infection Societies (FIS) annual conference
  • Place of Presentation: Liverpool, UK
  • Year and Date: 20121119-21
• [Presentation] 2011年東日本大震災直後の東北大学病院における感染症症例の解析 (2012)
  • Author(s): 青柳哲史、山田充啓、國島広之、徳田浩一、矢野寿一、石橋令臣、八田益充、遠藤史郎、新井和明、猪股真也、具芳明、金森肇、北川美穂、平潟洋一、賀来満夫
  • Organizer: 第86回日本感染症学会総会・学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 20120425-26
• [Presentation] Analysis of infectious diseases in the aftermath of the 2011 Tohoku earthquake and tsunami : the threat of pneumonia to survivors (2011)
  • Author(s): Aoyagi T, Yamada M, Kunishima H, Tokuda K, Yano H, Ishibashi N, Hatta M, Endo S, Arai K, Kanamori H, Kitagawa M, Hirakata Y, and Kaku M
  • Organizer: The 49th Annual Meeting of the Infectious Diseases Society of America (IDSA)
  • Place of Presentation: Boston, USA
  • Year and Date: 20111020-23