Excessive Inflammation and Severe Pneumonia; Approach toAnti-inflammatory Therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791137
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: MORINAGA Yoshitomo 長崎大学, 医歯薬学総合研究科, 助教 (30580360)
• Project Period (FY): 2011 – 2012
• Keywords: 肺炎 / 抗炎症 / HMGB1 / ネクローシス

Research Abstract

We studied the effectiveness of anti-inflammatory therapeutic approaches against severe lung infections. Legionella induced necrotic cell death with releasing inflammatory mediator, HMGB1,via cathepsin B activation. Cathepsin B inhibitor or recombinant thrombomodulin improved the inflammatory findings and weight changes in the mouse model of severe Legionella infection. Thrombomodulin also contributed to the treatment of Staphylococcus aureus lung infection

Research Products

• [Journal Article] Identification error of Aeromonas aquariorum: A causative agent of septicemia (2013)
  • Author(s): Morinaga Y, Yanagihara K, Eugenin FL, Beaz-Hidalgo R, Kohno S, Figueras Salvat MJ
  • Journal Title: Diagn Microbiol Infect Dis Volume: S0732-8893(13) Pages: 00055-2
  • DOI: doi:10.1016/j.diagmicrobio.2013.01.019
• [Journal Article] Live Legionella pneumophila induces MUC5AC production by airway epithelial cells independently of intracellular invasion (2012)
  • Author(s): Morinaga Y, Yanagihara K, Araki N, Migiyama Y, Nagaoka K, Harada Y, Yamada K, Hasegawa H, Nishino T, Izumikawa K, Kakeya H, Yamamoto Y, Kohno S, Kamihira S
  • Journal Title: CanadianJournal of Microbiology Volume: 58 Pages: 151-157
  • DOI: DOI:10.1139/w11-123
• [Presentation] Effects Of Recombinant Thrombomodulin In Combination WithAntibiotics On A Murine LegionellaPneumonia Model (2012)
  • Author(s): Morinaga Y, Yanagihara K, Kaku N,Migiyama Y, Nagaoka K, Harada Y, Yamada K, Izumikawa K, Kakeya H, Yamamoto Yand Kohno S
  • Organizer: 52^nd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 20120000
• [Presentation] Effects of dagibatran on a murine model of Staphylococcus aureushematogenous pulmonary infection (2012)
  • Author(s): Morinaga Y, Yanagihara K, Kaku N,Migiyama Y, Harada Y, Nagaoka K, Yamada K, Izumikawa K, Kakeya H, Yamamoto Yand Kohno S
  • Organizer: 52^nd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 20120000
• [Presentation] Clinical and Microbial Characteristics of Aeromonas Infections in a Japanese Hospital (2012)
  • Author(s): Morinaga Y, Yanagihara K, Araki N, HaradaY, MigiyamaY, Nagaoka K, Yamada K, Akamatsu N, Matsuda J, Hasegawa H, Izumikawa K, Kakeya H, Yamamo to Y, Yasuoka A, Kohno S and Kamihira S
  • Organizer: 112^th ASM
  • Place of Presentation: San Francisco
  • Year and Date: 20120000
• [Presentation] Aeromonas属菌の遺伝子学的再同定と病原性の検討 (2012)
  • Author(s): 森永芳智,柳原克紀,賀来敬仁,原田陽介,右山洋平,長岡健太郎,山田康一,泉川公一,掛屋 弘,山本善裕,河野 茂
  • Organizer: 第82回日本感染症学会西日本地方会
  • Place of Presentation: 福岡
  • Year and Date: 20120000
• [Presentation] レジオネラによるIL-1β産生に対するCRPの抑制効果 (2012)
  • Author(s): 森永芳智,柳原克紀,荒木伸子,右山洋平,原田陽介,長岡健太郎,山田康一,泉川公一,掛屋 弘,山本善裕,河野 茂,上平 憲
  • Organizer: 第86回日本感染症学会総会
  • Place of Presentation: 長崎
  • Year and Date: 20120000
• [Presentation] マウスレジオネラ肺炎モデルにおける抗菌薬併用下でのリコンビナントトロンボモジュリンの効果 (2012)
  • Author(s): 森永芳智,柳原克紀,荒木伸子,右山洋平,原田陽介,長岡健太郎,山田康一,泉川 公一,掛屋 弘,山本 善裕,河野 茂,上平 憲
  • Organizer: 第60回日本化学療法学会総会
  • Place of Presentation: 長崎
  • Year and Date: 20120000
• [Presentation] 気道分泌に対するマクロライド系薬2薬剤の併用効果 (2012)
  • Author(s): 森永芳智,柳原克紀,荒木伸子,原田陽介,右山洋平,長岡健太郎,山田康一,泉川公一,掛屋 弘,山本善裕,河野 茂,上平 憲
  • Organizer: 第60回日本化学療法学会総会
  • Place of Presentation: 長崎
  • Year and Date: 20120000
• [Presentation] The efficacy of the combination of azithromycin and clarithromycin on MUC5AC production in airway epithelial cells (2012)
  • Author(s): Morinaga Y, Yanagihara K, Araki N,Migiyama Y, Nagaoka K, Harada Y, Yamada K, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S and Kamihira S
  • Organizer: 51^st ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 20120000
• [Presentation] Aeromonas感染症の臨床的・微生物学的検討 (2011)
  • Author(s): 森永芳智,柳原克紀,荒木伸子,右山洋平,原田陽介,長岡健太郎,山田康一,赤松紀彦,松田淳一,中村茂樹,今村圭文,宮崎泰可,泉川公一,掛屋 弘,山本善裕,河野 茂,上平 憲
  • Organizer: 第59回日本化学療法学会西日本支部総会
  • Place of Presentation: 奈良
  • Year and Date: 20110000
• [Presentation] 仮性肺動脈瘤を伴ったStreptococcus constellatusによる肺化膿症の1例 (2011)
  • Author(s): 黒部昌也,森永芳智,大島一浩,中村茂樹,今村圭文,宮崎泰可,泉川公一,掛屋 弘,山本善裕,柳原克紀,河野 茂,上平 憲
  • Organizer: 第81回日本感染症学会西日本地方会
  • Place of Presentation: 福岡
  • Year and Date: 20110000
• [Presentation] Aeromonas敗血症7例の臨床像 (2011)
  • Author(s): 森永芳智,柳原克紀,荒木伸子,原田陽介,山田康一,松田淳一,中村茂樹,今村圭文,宮崎泰可,泉川公一,掛屋 弘,山本善裕,河野 茂,上平 憲
  • Organizer: 第81回日本感染症学会西日本地方会
  • Place of Presentation: 福岡
  • Year and Date: 20110000