Epidemiology and pathophysiology of lipoprotein glomerulopathy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791149
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Yamagata University
• Principal Investigator: HASHIMOTO Taeko 山形大学, 医学部, 助教 (30507629)
• Project Period (FY): 2011 – 2012
• Keywords: リポ蛋白糸球体症 / ApoE-Sendai / アポリポ蛋白E

Research Abstract

We screened for APOE-Sendai in newborns to study the frequency of LPG of APOE-Sendai , and also we screened for the patients with renal insufficiency in Yamagata Prefecture. We did not identify any newborns and patients with renal failure carrying APOE-Sendai. These findings indicate that the APOE-Sendai mutation is very rare in the general population.

Research Products

• [Journal Article] A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy (2013)
  • Author(s): Toyota K, Hashimoto T, Ogino D, Matsunaga A, Ito M, Masakane I, Degawa N, Sato H,Shirai S, Umetsu K, Tamiya G, Saito T, Hayasaka K
  • Journal Title: J Hum Genet
  • DOI: DOI:10.1038/jhg.2013.8
  • Peer Reviewed
• [Journal Article] 山形県における2 例目の小児リポ蛋白糸球体症 (2011)
  • Author(s): 橋本多恵子, 豊田健太郎, 荻野大助, 松永明, 早坂清
  • Journal Title: 日本小児腎臓病学会雑誌 Volume: 24 Pages: 218-223
  • Peer Reviewed
• [Presentation] リポ蛋白糸球体症の疫学 (2012)
  • Author(s): 豊田健太郎, 橋本多恵子, 荻野大助, 早坂清
  • Organizer: 第47回山形県小児保健会研修会平成23 度山形県小児保健会委託研究報告
  • Place of Presentation: 山形
  • Year and Date: 20121000
• [Presentation] A second pediatric patient with lipoprotein glomerulopathy carring a heterozygous Apo E Sendai mutation (2011)
  • Author(s): Taeko Hashimoto, Kentaro Toyota, Akira Matsunaga and Kiyoshi Hayasaka
  • Organizer: The 11th Asian congress of pediatric nephrology
  • Place of Presentation: Fukuoka Japan
  • Year and Date: 20110600