2012 Fiscal Year Final Research Report
Isolation of myogenic stem/progenitors fromhuman ES/iPS cells.
| Project/Area Number |
23791170
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
AWAYA Tomonari 京都大学, 大学院・医学研究科, 助教 (20589593)
|
|---|
| Research Collaborator |
KATO Takeo 京都大学, 大学院医学研究科, 助教 (60422945)
HEIKE Toshio 京都大学, 大学院医学研究科, 教授 (90190173)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ES細胞 / Ips細胞 / 骨格筋 / 筋疾患 / 筋ジストロフィー / サテライト細胞 / 細胞治療 / 再生医療 |
|---|
| Research Abstract |
We developed a novel skeletal myogenic differentiation protocol for human embryonic stem (ES) and induced pluripotent stem (iPS) cells in vitro. We also demonstrated the in vivoengraftment capacity of the generated cells in pre-damaged muscles of immunodeficient mice. These cells partially committed to muscle satellite cells as well, exhibiting long-term sustainable muscle reconstruction. These observations encourage the further use of human ES and iPS cells in regenerative medicine.
|
