2013 Fiscal Year Final Research Report
Importance of Urinary Bone Resorptive Marker in Diagnosis and Classification of Osteogenesis Imperfecta
| Project/Area Number |
23791177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Hiroyuki 岡山済生会総合病院, 小児科, 部長
YAMASHITA Miho 岡山大学, 岡山大学病院, 助教
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨形成不全症 / I型コラーゲン / ピリジノリン架橋 / I型コラーゲン架橋N-テロペプチド |
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| Research Abstract |
We analyzed whether urinary N-telopeptide of type I collagen become a diagnostic marker of patients with infantile osteogenesi imperfecta. Urinary NTX value in OI patients is significantly lower than that of healthy infant although overlap between two groups was observed. In one month old, urinary NTX value in OI infants is significantly lower than healthy control without overlap and without relation to height and body weight. From these results, urinary NTX value at one month old might become a diagnostic marker of OI infants.
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