2013 Fiscal Year Final Research Report

Metabolic and immunological impacts of growth hormone treatment in children with short stature born small for gestational age

Research Project

Project/Area Number	23791184
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	Kyushu University
Principal Investigator	ISHII Kanako 九州大学, 大学病院, 特任講師 (90400332)
Project Period (FY)	2011 – 2013
Keywords	SGA性低身長 / 成長ホルモン / 脂質代謝
Research Abstract	We studied on metabolic and immunological effects by growth hormone treatment (GH Tx) for one year in children with short stature born small for gestational age (SGA). We also evaluated the metabolic and immunological parameters for the patients before GH Tx compared with those for healthy controls. As a result, height SDS was improved 3 months after starting GH Tx in proportion to increase of serum IGF1 level. The HbA1c level before GH Tx in SGA children was higher than in controls, however, it did not worsen after GH Tx. The LDL-C level decreased by GH Tx, which indicated favorable effects of GH on lipid metabolism. Similarly, the many of serum apolipoprotein levels were considerably altered by GH Tx. Differences in counts of the white blood-cell, the neutrophil and the lymphocyte, and population of lymphocyte subsets were observed in between the patients before GH Tx and controls. GH Tx for the patients changed the levels of these hematological parameters toward those in controls.