2012 Fiscal Year Final Research Report
Abnormalities of intracellular signaling in the cerebral cortex of neurodevelopmental disorder model mice.
| Project/Area Number |
23791188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 大脳皮質 / 神経栄養因子 |
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| Research Abstract |
The neurodeveloping disorder model mice were made by injection Poly I:C, a synthetic analog of double-stranded RNA, to pregnant mice. The Poly I:C- treated mice offspring didn’t learn cue-guided radial maze task efficiently. The number of pERK1/2 positive cells was significantly decreased in the cerebral cortex of Poly I:C-treated mice after the last task. The results obtained in this study suggest that the alterations of pERK1/2 expression in the cerebral cortex might cause the learning defect in the Poly I:C-treated mice.
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