2013 Fiscal Year Final Research Report
| Project/Area Number |
23791198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SHIMIZU Mikiko 東京女子医科大学, 医学部, 助教 (40338968)
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| Project Period (FY) |
2011 – 2013
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| Keywords | チアノーゼ性先天性心疾患 / P-selectin / 低酸素血症 / フォンタン手術 |
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| Research Abstract |
1. Platelet P-selectin expression was enhanced in patients with cyanotic congenital heart disease (CCHD). 2. Platelet aggregation was enhanced in patients with CCHD. 3. In patients with thromboembolism, platelet P-selectin expression was enhanced. 4. Factors related with platelet activation were cyanosis and Fontan operation. 5. Platelet activation was related with endothelial dysfunction, measured by serum thrombomodulin concentration.
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