The establishment of a novel diagnostic system of gastroesophageal reflux disease in neurologically impaired children

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kurume University
• Principal Investigator: FUKAHORI Suguru 久留米大学, 医学部, 助教 (90299488)
• Project Period (FY): 2011 – 2012
• Keywords: 先天性消化管疾患学

Research Abstract

Combined pH - Multichannel Intraluminal Impedance Measurements and 13C-acetate breathtest were conducted to 63 and 31 neurologically impaired (NI) children for 2 years, respectively. The results of the analysis of each device’s parameters were reported. NI children with pathological GERD showed more reflux episodes reaching proximal esophagus than the others. NI children after fundoplication might have slight esophageal dysmotility. All NI children showeddelayed gastric emptying.

Research Products

• [Journal Article] Yagi MPre and Post-operative Evaluation of Gastroesophageal Reflux and Esophageal Motility in Neurologically Impaired Children Using Combined pH - Multichannel (2013)
  • Author(s): Fukahori S, Asagiri K, Ishii S, Tanaka Y,Kojima S, Saikusa N, Koga Y, Yoshida M, Masui D, Komatsuzaki N, Seki Y
  • Journal Title: Intraluminal Impedance Measurements Pediatr Surg Int Volume: 29(6) Pages: 545-51
  • DOI: doi:10.1007/s00383-013-3295-7.
• [Presentation] Kimio Asagiri and Yoshiaki TanakaEvaluation of Gastric Emptying measured by 13C-acetate breath test in NeurologicallyImpaired Children (2012)
  • Author(s): Shinji Ishii, Minoru Yagi, Suguru Fukahori, Naoko Komatsuzaki, Motomu Yoshida, Yoshinori Koga, Shinichiro Kojima, Nobuyuki Saikusa
  • Organizer: The 25thInternational Symposium on Paediatric Surgical Research London
  • Place of Presentation: UK
  • Year and Date: 20120921-0922
• [Presentation] Daisuke Masui, Naoko Komatsuzaki, and Minoru YagiPre and Post-operative Evaluation of Gastroesophageal Reflux and Esophageal motility in Neurologically Impaired Children Using Combined pH - Multichannel Intraluminal Impedance Measurements (2012)
  • Author(s): Suguru Fukahori, Kimio Asagiri, Shinji Ishii, Yoshiaki Tanaka, Shin-ichiro Kojima, Nobuyuki Saikusa, Yoshinori Koga, Motomu Yoshida
  • Organizer: The 25th International Symposium onPaediatric Surgical Research London
  • Place of Presentation: UK
  • Year and Date: 20120921-0922
• [Presentation] 八木 実24 時間食道インピーダンスを用いた重症心 身障がい児の GERD と食道運動機能の評価 (2012)
  • Author(s): 深堀 優 ,石井信二,浅桐公男, 田 中芳明,田中宏明,小島伸一郎,古賀義法, 升 井大介,小松崎尚子
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20120514-0516
• [Presentation] 重症心身障害者における胃排出能の検討 (2012)
  • Author(s): 石井信二,深堀優,八木実,小松崎尚子,吉田索,古賀義法,小島伸一郎,七種伸行,浅桐公男,田中芳明
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20120514-0516
• [Presentation] 食道pHインピーダンス法を用いた小児胃食道逆流症の病態把握 (2011)
  • Author(s): 深堀優,小松崎尚子,升井大介,古賀義法,小島伸一郎,石井信二,田中宏明,浅桐公男,田中芳明,八木実
  • Organizer: 第8回日本消化管学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20110210-0211
• [Presentation] Kimio Asagiri and Yoshiaki TanakaThe utility of esophageal combined pH - multichannel intraluminal impedance measurements: the experience of our institution and the new trial (2010)
  • Author(s): Suguru Fukahori, Minoru Yagi, Shinji Ishii, Daisuke Masui, Naoko Komatsuzaki, Yoshinori Koga, Shinichiro Kojima, Hiroaki Tanaka
  • Organizer: The 24th International Symposium onPaediatric Surgical Research Graz
  • Place of Presentation: Austria
  • Year and Date: 20101008-1009