2012 Fiscal Year Final Research Report
Exploring genetic susceptibility to food allergy in innate and mucosal immunity genes
| Project/Area Number |
23791204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HIROTA Tomomitsu 独立行政法人理化学研究所, 呼吸器疾患研究チーム, 研究員 (50435674)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食物アレルギー / 関連遺伝子 / 自然免疫 / 粘膜免疫 |
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| Research Abstract |
The prevalence of food allergy has increased over the past two decades in Japan. To elucidate the pathological mechanisms underlying food allergy, we conducted case-control studies using 600 food allergy patients and 1900 controls. As a result, we identified a significant association between a SNP of IL13 gene and food allergy (p<0.01). In subgroup analysis, the association between the SNP of IL13 and food allergy was enhanced in subgroups patients with bronchial asthma and with atopic dermatitis.
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