2013 Fiscal Year Final Research Report
Identification of host cell factors relating the replication of respiratory syncytial virus
| Project/Area Number |
23791205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SHIRATO Kazuya 国立感染症研究所, ウイルス第3部, 主任研究官 (40415477)
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| Project Period (FY) |
2011 – 2013
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| Keywords | RSV / MDCK / ウイルス複製 |
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| Research Abstract |
Respiratory syncytial virus (RSV) is a major causative agent of respiratory tract infections in children worldwide. Preterm children are at a particularly high risk of developing severe and lethal RSV infections. Because effective vaccines are not available, it is urgently necessary to develop antivirus drugs like oseltamivir for influenzavirus. In this study, we tried to identify host cell factors relating the replication of RSV using low-susceptible cell line, MDCK, and cDNA library derived from susceptible cells. As the results, expression of Ephrin-B2, RARRES2, and CCL2 increased the replication of RSV in MDCK. In future, it is necessary to clarify precise roles of these molecules in the replication of RSV.
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