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2012 Fiscal Year Final Research Report

Identification of new biomarkers for the prediction of disease onset and for therapy evaluation in preterm infants with bronchopulmonary dysplasia

Research Project

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Project/Area Number 23791219
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionUniversity of Fukui

Principal Investigator

TOKURIKI Shuko  福井大学, 医学部, 助教 (60510237)

Project Period (FY) 2011 – 2012
Keywords未熟児医学
Research Abstract

Here, we examined levels of carboxyhemoglobin (CO-Hb) and methemoglobin (Met-Hb), markers of CO production and NO production, respectively, and discuss the usefulness of these markers to predict bronchopulmonary dysplasia (BPD) in preterm infants. CO-Hb levels in infants with moderate/severe BPD on postnatal days 5-7 were significantly higher than those in infants with no/mild BPD. Levels of urinary oxidative stress markers, i.e., advanced oxidative protein product (AOPP) and 8-hydroxydeoxyguanosine (8-OHdG), in infants with moderate/severe BPD also tended to be higher than those in infants with no/mild BPD on postnatal days 5-7. Thus, our data suggest that high levels of CO-Hb during the early neonatal period may reflect induction of hemeoxygenase-1 (HO-1) by oxidative stress and that CO-Hb levels are useful for early prediction of moderate/severe BPD in preterm infants.

  • Research Products

    (4 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Biotin and carnitine profiles in preterm infants in Japan2013

    • Author(s)
      Tokuriki S, Hayashi H, Okuno T, Yoshioka K, Okazaki S, Kawakita A, Ohta G, Hata I, Shigematsu Y, Ohshima Y
    • Journal Title

      Pediatr Int.

    • Peer Reviewed
  • [Journal Article] Immunotherapy with oligomannose-coated liposomes ameliorates allergic synptoms in a murine allergy model2012

    • Author(s)
      Kawakita A, Shirasaki H, Yasutomi M, Tokuriki S, Mayumi M, Naiki H, Ohshima Y
    • Volume
      67(3)
    • Pages
      371-9
    • Peer Reviewed
  • [Presentation] 早産児におけるビオチン・カルニチンの潜在的欠乏についての検討2012

    • Author(s)
      徳力周子, 河北亜希子, 巨田元礼, 重松陽介 , 大嶋勇成
    • Organizer
      第48回日本周産期新生児医学会学術集会
    • Place of Presentation
      さいたま市
    • Year and Date
      20120708-10
  • [Presentation] 当院における超低出生体重児の発達予後2011

    • Author(s)
      徳力周子, 河北亜希子, 米谷博, 川谷正男, 畑郁江, 大嶋勇成
    • Organizer
      第25回北陸周産期新生児研究会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-16

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Published: 2014-09-25  

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