2012 Fiscal Year Final Research Report

Genetic mutations and polymorphisms of axon guidance factors in the development of human retinopathy of prematurity

Research Project

Project/Area Number	23791223
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Embryonic/Neonatal medicine
Research Institution	Kobe University
Principal Investigator	MIWA Akihiro 神戸大学, 医学部附属病院, 特定助教 (70457076)
Project Period (FY)	2011 – 2012
Keywords	未熟児網膜症 / エリスロポエチン / 一塩基多型
Research Abstract	Among axon guidance factors, we focused on erythropoietin (EPO), and investigated correlation between the development of retinopathy of prematurity (ROP) and allele A frequency of rs1617640, which was a single nucleotide polymorphism in the promoter area of EPOgene. Forty-four neonates with ROP and 62 non-ROP neonates born before 32 weeks of gestations were examined. There were no significant differences in allele A frequency and genotype frequency between the groups. A logisticmultiple regression analysis revealed that supplementation of human recombinant EPO was a risk factor for the development of ROP. Exogenous EPO, not endogenous EPO seems to be a risk factor for the development of ROP.