2013 Fiscal Year Final Research Report
Genetic analysis of patent ductus arteriosus in preterm infants.
| Project/Area Number |
23791234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUGIURA Tokio 名古屋市立大学, 医学(系)研究科(研究院), 助教 (10381881)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 動脈管開存症 / 遺伝子多型 / インドメタイン / 早産児 |
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| Research Abstract |
Patent ductus arteriosus is a common morbidity associated with preterm birth. Our major goal was to determine if genetic risk factors play a role in patient ductus arteriosus seen in preterm infants. DNA samples collected from 80 infants with a gestational age less than 32 weeks. There were 41 boys and 39 girls. Mean gestational age was 29 weeks (22-31 weeks), mean birth weight was 1059g (476-2158g). Natural close of ductus arteriosus was seen in 30% in infants, indomethacin with one time was used in 46% in infants, and indomethacin with two times were used in 23% in infants. Surgical closure of ductus arteriosus was proceeded in 7% in infants. We investigated single nucleotide polymorphism in transcription factor AP-2 by real time polymerase chain reaction.
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[Journal Article] Viral load before and after exchange transfusion in a neonate with hyperbilirubinemia and congenital cytomegalovirus infection2014
Author(s)
Ohashi K, Ito K, Endo T, Sugiura T, Awaya R, Goto T, Nagaya Y, Ueda H, Nagasaki R, Kato T, Saitoh S.
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Journal Title
J Clin Case Rep
Volume: 4
Pages: 1-2
DOI
Peer Reviewed
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[Journal Article] Hypothermia attenuates the severity of oxidative stress development in asphyxiated newborns2012
Author(s)
Kakita H, Hussein MH, Kato S, Yamada Y, Nagaya Y, Asai H, Goto T, Ito K, Sugiura T, Daoud GA, Ito T, Kato I, Togari H.
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Journal Title
J Crit Care
Volume: 27
Pages: 469-473
DOI
Peer Reviewed
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[Presentation] Exchange transfusion was not effective to reduce viral load in congenital cytomegalovirus infection2013
Author(s)
Kei Ohashi, Koichi Ito, Takeshi Endo, Tokio Sugiura, Risa Away, Tatenobu Goto, Hiroko Ueda, Rika Nagasaki, Takenori Kato, Shinji Saitoh
Organizer
11th World Congress of Perinatal Medicine
Place of Presentation
Moscow, Russia
Year and Date
20130619-22
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[Presentation] Survival of fetuses with oligohydramnios2013
Author(s)
Hajime Tanaka, Tatenobu Goto, Tokio Sugiura, Risa Awaya, Hiroko Ueda, Koichi Ito, Hiroki Kakita, Rika Nagasaki, Takenori Kato, Shinji Saitoh
Organizer
11th World Congress of Perinatal Medicine
Place of Presentation
Moscow, Russia
Year and Date
20130619-22
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[Presentation] Rapidly progressive hepatomegaly in an infant with stage 4S neuroblastoma2012
Author(s)
Atsushi Suzuki, Michi Kamei, Yasuhiko Ito, Kouichi Ito, Tsuyoshi Endo, Tokio Sugiura, Shinji Saitoh, Youko Sato, Satoshi Kondo, Daisuke Takagi, Tatuya Suzuki, Satoshi Ishikura
Organizer
4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
Place of Presentation
Taipei, Taiwan
Year and Date
20121114-17
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[Presentation] Massive intracranial hemorrhage caused by neonatal alloimmune thrombocytopenia associated with anti-group A antibody2011
Author(s)
Kohei Aoyama, Shin Kato, Tokio Sugiura, Hiroko Ueda, Koichi Ito, Hiroki Kakita, Ineko Kato, Kinuyo Kawabata, Hitoshi Ohto, Hajime Togari
Organizer
10th World Congress of Perinatal Medicine
Place of Presentation
Punta del Este, Uruguay
Year and Date
20111108-11
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[Presentation] Cytokine profiles before, during, and after exchange transfusion in the preterm infant with necrotizing enterocolitis2011
Author(s)
Satoru Takeshita, Tokio Sugiura, Masanori Kouwaki, Kenji Goto, Takeshi, Endo, Koichi Ito, Norihisa Koyama, Hajime Togari
Organizer
10th World Congress of Perinatal Medicine
Place of Presentation
Punta del Este, Uruguay
Year and Date
20111108-11
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