2013 Fiscal Year Final Research Report
A study on the kinetics of bradykinin and cytokines in the low volume hemofilter with blood priming
| Project/Area Number |
23791235
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TAKADA Akira 岩手医科大学, 医学部, 助教 (30438494)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 新生児 / 血液浄化療法 / 血液充填 / サイトカイン / 電解質 / 酸塩基平衡 |
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| Research Abstract |
In blood purification therapy for neonates, the extracorporeal circuit is primed by banked blood. Proinflammatory cytokines included IL-6, IL-1beta and TNF-alpha were low concentration in the primed blood mixed by banked red cell and 5% albumin. Also, these concentrations were no change using with polysulfon membrane or polymethyl methacrylate membrane. The concentration of sodium, potassium, calcium, glucose, lactate and bicarbonate in the primed blood were normalized by dialysis more than for 20 minites.
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