2013 Fiscal Year Final Research Report
atmospheric pressure plasma inhalation as a treatment for hypoxic-ischemic encephalopathy
| Project/Area Number |
23791237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2013)
Tokai University (2011-2012) |
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Principal Investigator |
KONDO AKANE 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, その他部局等, 周産期医長 (00384884)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大気圧プラズマ / 低酸素脳症 / 血管内皮 / 一酸化酸素 |
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| Research Abstract |
Atmospheric plasma has been used as clinical treatment equipment originally for thermal burn, and recently this equipment is applied for diabetic skin ulcer. These previous studies showed that plasma have an effect on cell proliferation through cell growth factor. In this study, we examined the effect of inhalation of atmospheric plasma on hypoxic encephalopathy with rat model. Neonatal hypoxic encephalopathy is very difficult condition and there is no effective treatment for damaged brain at present. This study showed that inhalation of plasma could introduce angiogenesis and neurogenesis. The result also showed that inhalation of plasma effect on hemodynamics such as reducing blood pressure and gaining the heart rate. These effects are suspected to relate to nitric oxide produced by vascular endothelial cell.
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