2012 Fiscal Year Final Research Report

Investigation of diagnostic and prognostic markers of severe cutaneous adverse drug reactions

Research Project

Project/Area Number	23791243
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Hokkaido University
Principal Investigator	MURATA Jyunko 北海道大学, 大学院・医学研究科, 非常勤講師 (10598387)
Project Period (FY)	2011 – 2012
Keywords	皮膚炎症 / 再生学
Research Abstract	Severe cutaneous adverse drug reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) are life-threating diseases. In this project, we investigated to identify diagnostic and prognostic markers using patients’ PBMCs. Patients’ PBMCs were stimulated with causative drugs and mRNA and proteins were collected. These mRNA and proteins profiles were compared to those of non-severe cutaneous adverse drug reactions (maculopapular tyoe). We identified sFasL and granulysin are the markers.

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