Analyses of SIRT6 function in preventing ultraviolet B-induced skin damages

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: ROKUNOHE Daiki 弘前大学, 医学(系)研究科(研究院), 助教 (50436036)
• Project Period (FY): 2011 – 2012
• Keywords: 皮膚炎症 / 再生学 / 寿命 / 紫外線皮膚障害 / 皮膚悪性腫瘍

Research Abstract

We established SIRT6 transgenic mice. SIRT6, which plays important roles in DNA repair pathways, is overexpressed in epidermis of those TG mice. We irradiated UVB on the back of those TG mice, and analyzed acute and chronic skin damages. We demonstrated SIRT6 protein overexpression in epidermis inhibited UVB-induces acute erythema, and suppressed chronic skin damages.

Research Products

• [Journal Article] Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A (2012)
  • Author(s): Rokunohe D, Akasaka E, Rokunohe A, Kaneko T, Matsuzaki Y, Takiyoshi N, Aizu T, Nakano H, Sawamura D
  • Journal Title: J Dermatol Case Rep Volume: 6 Pages: 40-42
  • DOI: doi:10.3315/jdcr.2012.1096.
  • Peer Reviewed
• [Journal Article] A Case of Erythema Nodosum Associated with Subareolar Abscess (2012)
  • Author(s): Minakawa S, Matsuzaki Y, Rokunoke D, Akasaka E, Nakajima K, Aizu T,Kaneko T, Nakano H, Takashima T, Sawamura D
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 2 Pages: 263-264
  • DOI: doi:10.4236/jcdsa.2012.24049
  • Peer Reviewed
• [Journal Article] Spindle Cell Hemangioma and Decorin Expression. (2012)
  • Author(s): Rokunohe D, Takeda H, Kaneko T, Aizu T, Akasaka E, Matsuzaki Y, Nakano H, Sawamura D
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 2 Pages: 8-10
  • DOI: doi:10.4236/jcdsa.2012.21002
  • Peer Reviewed
• [Presentation] 放射線角化症の2例 (2013)
  • Author(s): 金子高英、六戸亜希子、六戸大樹、中島康爾、会津隆幸、中野創、澤村大輔
  • Organizer: 第81回日本皮膚科学会茨城地方会
  • Place of Presentation: つくば市
  • Year and Date: 20130309-10
• [Presentation] 踵に生じミルメシア様の外観を呈した顆粒細胞腫の1例 (2012)
  • Author(s): 六戸大樹、金子高英、六戸亜希子、竹内園子、木村一之、中野創、澤村大輔、板井恒二
  • Organizer: 第76回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 20120929-30
• [Presentation] 原発不明悪性黒色の4例 (2012)
  • Author(s): 金子高英、福井智久、六戸亜希子、是川あゆ美、六戸大樹、中島康爾、会津隆幸、中野創、澤村大輔、原田研
  • Organizer: 第76回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 20120929-30
• [Presentation] アダリムマブ投与後に掌蹠膿疱症が再燃し全身に膿疱が多発した関節リウマチの1例 (2012)
  • Author(s): 六戸大樹、北村英夫,原田研、金澤洋、三上幸子
  • Organizer: 日本皮膚科学会青森地方会第358回例会
  • Place of Presentation: 弘前市
  • Year and Date: 2012-04-08
• [Presentation] 白斑黒皮症を呈した慢性光線性皮膚炎の1例 (2012)
  • Author(s): 金子高英、六戸大樹、六戸亜希子、中野創、澤村大輔
  • Organizer: 日本皮膚科学会青森地方会第358回例会
  • Place of Presentation: 弘前市
  • Year and Date: 2012-04-08