2012 Fiscal Year Final Research Report
The effect of myeloid derived suppressor cells on the induction of peripheral tolerance
| Project/Area Number |
23791249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUJIMURA Taku 東北大学, 大学院・医学系研究科, 助教 (50396496)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 皮膚腫瘍学 |
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| Research Abstract |
We invstigated mainly mouse immunosuppressive macrophages and myeloid derived suppressor cells, as well as regulatory T cells on the induction of peripheral tolerance in cancer patient and cancer bearing mouse. By this project, we have published 8 English papers concerned about the effect of immunosuppressive macrophages on cancer microenvironment. Another 5 English papers are still under submission. Through this project, wecharacterized the further subtypes of immunosuppressive macrophages, and in future, by targeting these macrophages in cancer patients, further optimal therapy might be established.
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