2013 Fiscal Year Final Research Report

Structure of Sebosomes, secret membrane vesicles of cultured sebocytes

Research Project

Project/Area Number	23791274
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Ehime University
Principal Investigator	NAGAI Ayako 愛媛大学, 医学部附属病院, 助教(特定教員) (90420562)
Project Period (FY)	2011 – 2013
Keywords	セボゾーム / 脂腺細胞 / ヒストン / 抗菌 / 分泌膜小胞
Research Abstract	Rat cultured sebocytes synthesized and secreted sebosomes. The sebosomes contained multiple subcellular organelles such as exosomes, plasma membrane, endosomes, lysosomes, lipid particles and lipid rafts, suggesting that the secretory mechanism of the sebosomes was different from that of exosomes. Newly synthesized proteins including histones were detected both in the de novo synthesized sebosomes and nuclei in cultured sebocytes. It was suggested that the organelles were continuously and actively localized to the sebosomes. The sebosomes were suggested to supply multiple molecules, lipids and proteins to keratinocytes and surrounding cells.

(4 results)