Research for anti-inflammatory and redox effects of antifungal drug in the skin

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kyushu University
• Principal Investigator: TAKAHARA Masakazu 九州大学, 大学病院, 講師 (20398093)
• Project Period (FY): 2011 – 2012
• Keywords: 皮膚炎症 / 再生学

Research Abstract

We demonstrated that ketoconazole exerted anti-inflammatory effects in addition to an anti-fungal effect in human skin keratinocytes. The effects are dependent on activation of aryl hydrocarbon receptor (AhR), which induced Nrf2 and NQO1 leading to inhibition of ROS, IL-8 production, and DNA damage

Research Products

• [Journal Article] Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect (2012)
  • Author(s): Gaku Tsuji, Masakazu Takahara, Hiroshi Uchi, Tetsuo Matsuda, Takahito Chiba, Satoshi Takeuchi, Fumiko Yasukawa, Yoichi Moroi, Masutaka Furue
  • Journal Title: J Invest Dermatol Volume: 132(1) Pages: 59-68
• [Journal Article] ビデンス・ピローサエキスによるヒト表皮細胞のNrf-2およびNqo1産生亢進 西日本皮膚科採用
  • Author(s): 高原正和、北和代、永江航之介、八谷顕子、日高らん、磯谷智世、土井和子、竹井賢二郎、古江増隆
• [Presentation] Immunomodulation by tobacco smoking: A possible mechanism exacerbating skin diseases (2012)
  • Author(s): Masakazu Takahara, Gaku Tsuji, Masutaka Furue
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20120524-0529
• [Presentation] an extract from artichoke, inhibits UVB-induced oxidative stress in cultured human keratinocytes (2012)
  • Author(s): Tsuji G, Takahara M, Yan X, Hachiya A, Uchi H, Takeuchi S, Yasukawa F, K. Takei K, Moroi Y, Furue M Cynaropicrin
  • Organizer: Society of Investigative Dermatology 72nd Annual meeting
  • Place of Presentation: Raleigh, USA
  • Year and Date: 2012-05-10
• [Presentation] Ketoconazole activates nuclear factor-erythroid 2-related factor-2 (Nrf2) via aryl hydrocarbon receptor signaling pathway: A possible mechanism of anti-inflammatory effect (2011)
  • Author(s): Tsuji G, Takahara M, Matsuda T, Uchi H, Takeuchi S, Mitoma C, Moroi Y, Furue M.
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20110524-0529
• [Presentation] Aryl hydrocarbon receptor modulates keratinocyte differentiation by SIRT1 expression (2011)
  • Author(s): Tsuji G, Takahara M, Uchi H, Takeuchi S, Yasukawa F, Moroi Y, Furue M
  • Organizer: SID 71st Annual Meeting
  • Place of Presentation: Phoenix, USA
  • Year and Date: 20110504-0507