2012 Fiscal Year Final Research Report
serum microRNA levels in skin diseases
| Project/Area Number |
23791279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
JINNIN Masatoshi 熊本大学, 大学院・生命科学研究部, 講師 (60401048)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 皮膚 / microRNA / 強皮症 |
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| Research Abstract |
In this project, we found that microRNA can be purified from serum by miRNeasy RNAisolation kit. We compared serum levels of various microRNAs between healthy controlsor disease controls and patients with scleroderma, psoriasis, melanoma, squamous cellcarcinoma, localized scleroderma or dermatomyositis. We also analyzed the correlationof serum microRNA levels and clinical/laboratory features in each disease. We suggesta possibility that serum microRNA levels can be useful markers for diagnosis or evaluatingdisease activities. Furthermore, we revealed that the intermittent overexpression oflet-7a in the mice skin by intraperitoneal injection attenuated the skin fibrosis inducedby bleomycin.
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[Journal Article] Angiopoietin-like protein 2 is animportant facilitator of inflammatorycarcinogenesis and metastasis2011
Author(s)
Aoi J, Endo M, Kadomatsu T, Miyata K,Nakano M, Horiguchi H, Ogata A, Odagiri H,Yano M, Araki K, Jinnin M, et al
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Journal Title
Cancer Res
Volume: 71巻
Pages: 7502-7512
Peer Reviewed
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