2012 Fiscal Year Final Research Report
Analysis of ma1,candidate responsible gene for atopic dermatitis, andelucidation of molecular mechanism for the dermatitis caused by ma1 deficiency
| Project/Area Number |
23791290
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
SHIOHAMA Aiko 慶應義塾大学, 医学部, 特任助教 (40383731)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アトピー性皮膚炎 / モデルマウス / ゲノムシーケンシング / フィラグリン |
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| Research Abstract |
We established matted mice （ma^-）strain previously, which develop spontaneousdermatitis in specific-pathogen-free conditions. And we examined Matted wasresponsible for the dermatitis phenotype and corresponds to a nonsense mutation inthe ma1 gene. The aim
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