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2012 Fiscal Year Final Research Report

The role of Histatin-1 ectopically expressed in human melanoma cells

Research Project

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Project/Area Number 23791293
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

YAGUCHI Tomonori  慶應義塾大学, 医学部, 助教 (40424163)

Project Period (FY) 2011 – 2012
Keywords悪性黒色腫
Research Abstract

HTN-1, a saliva-specific antimicrobial secretory peptide, was ectopically expressed inhuman MM and contributed to its metastatic capacity and immunosuppressive activity,suggesting that HTN-1 was an attractive diagnostic marker and a therapeutic target for

  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (12 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 化学療法・分子標的薬による免疫応答増強2013

    • Author(s)
      谷口智憲、河上裕
    • Journal Title

      医学のあゆみ

      Volume: 244 Pages: 817-823

    • URL

      http://www.ishiyaku.co.jp/magazines/ayumi/AyumiArticleDetail.aspx?BC=924409&AC=12297

  • [Journal Article] Autocrine and paracrine loops betweencancer cells and macrophages promotelymph node metastasis via CCR4/CCL22 inhead and neck squamous cell carcinoma2013

    • Author(s)
      Tsujikawa T, Yaguchi T, Ohmura G, Ohta S,Kobayashi A, Kawamura N, Fujita T,Nakano H, Shimada T, Takahashi T, NakaoR, Yanagisawa A, Hisa Y, Kawakami Y
    • Journal Title

      IntJ Cancer.

      Volume: 132 Pages: 2755-2766

    • DOI

      DOI:10.1002/ijc.27966

    • Peer Reviewed
  • [Journal Article] 特集 がん免疫学と免疫療法の新展開 7.分子標的薬を用いたがん免疫応答の制御2012

    • Author(s)
      谷口智憲、西尾浩、里見良輔、川村直、小林明日香、河上裕
    • Journal Title

      血液フロンティア

      Volume: 22 Pages: 1229-1238

    • URL

      https://www.iyaku-j.com/iyakuj/system/M2-1/summary_viewer.php?trgid=25341

  • [Journal Article] 特集 がん免疫学と免疫療法の新展開 1.がん免疫病態と免疫動態の評価2012

    • Author(s)
      河上裕、谷口智憲、中村公子、川瀬芳恵、野路しのぶ、大泉梓、南雲春菜、長谷川舞、徐明利、岡本正人、桜井敏晴、藤田知信
    • Journal Title

      血液フロンティア

      Volume: 22 Pages: 1183-1190

    • URL

      https://www.iyaku-j.com/iyakuj/system/M2-1/summary_viewer.php?trgid=253355

  • [Journal Article] Immune Suppression and ResistanceMediated by Constitutive Activation ofWnt/β-Catenin Signaling in HumanMelanoma Cells.2012

    • Author(s)
      Yaguchi T, Goto Y, Kido K, Mochimaru H,Sakurai T, Tsukamoto N, Kudo-Saito C,Fujita T, Sumimoto H, Kawakami Y
    • Journal Title

      J. Immunol

      Volume: 189 Pages: 2110-2117

    • DOI

      DOI:10.4049/jimmunol.1102282

    • Peer Reviewed
  • [Journal Article] FibroblastGrowth Factor-2 Is an Important Factor thatMaintains Cellular Immaturity andContributes to Aggressiveness ofOsteosarcoma2012

    • Author(s)
      Shimizu T, Ishikawa T, Iwai S, Ueki A,Sugihara E, Onishi N, Kuninaka S,Miyamoto T, Toyama Y, Ijiri H, Mori H,Matsuzaki Y, Yaguchi T, Nishio H,Kawakami Y, Ikeda Y, Saya H
    • Journal Title

      Mol Cancer Res

      Volume: 10 Pages: 454-68

    • DOI

      doi:10.1158/1541-7786.MCR-11-0347

    • Peer Reviewed
  • [Journal Article] ヒトがん細胞に対する免疫応答機構と免疫制御の可能性2011

    • Author(s)
      河上裕、小室美紗、小林明日香、梶原-岩田知子、宮崎潤一郎、川村直、谷口智憲.
    • Journal Title

      腫瘍内科

      Volume: 8 Pages: 409-416

    • URL

      http://www.kahyo.com/item/ON201111-085

  • [Journal Article] Themechanisms of cancer immunoescape anddevelopment of overcoming strategies2011

    • Author(s)
      Yaguchi T, Sumimoto H, Kudo-Saito C,Tsukamoto N, Ueda R, Iwata-Kajihara T,Nishio H, Kawamura N, Kawakami Y
    • Journal Title

      Int Jhematol

      Volume: 93 Pages: 294-300

    • DOI

      doi:10.1007/s12185-011-0799-6

  • [Journal Article] 特集「ヒト誕生・老化・疾患を運ぶエクソソーム」癌細胞由来エクソソームによる免疫系への作用とその臨床応用2011

    • Author(s)
      植田良、Li Qian、中村公子、谷口智憲、宮崎潤一郎、川村直、河上裕
    • Journal Title

      実験医学

      Volume: 29 Pages: 410-414

    • URL

      https://www.yodosha.co.jp/jikkenigaku/book/9784758100687/

  • [Journal Article] SEREX法によるヒト腫瘍抗原の単離と免疫療法への応用2011

    • Author(s)
      宮崎潤一郎、川村直、梶原-岩田知子、谷口智憲、河上裕
    • Journal Title

      細胞

      Volume: 43 Pages: 88-91

    • URL

      http://hokuryukan-ns.co.jp/magazines/archives/2011/02/20113_2.html

  • [Journal Article] 特集:膵癌・胆道癌に対する免疫治療、ワクチン療法の新展開樹状細胞抑制による抗腫瘍免疫増強2011

    • Author(s)
      川村直、宮崎潤一郎、梶原-岩田知子、谷口智憲、河上裕
    • Journal Title

      胆と膵

      Volume: 32 Pages: 123-127

    • URL

      http://www.igakutosho.co.jp/magazine/t_s/2011/zt3202.html

  • [Journal Article] 癌微小環境におけるPD-L1/PD-1による免疫抑制病態とその是正2011

    • Author(s)
      川村直、谷口智憲、桜井敏晴、河上裕
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 1-6

    • URL

      http://www.kahyo.com/item/M201107-561

  • [Presentation] Altered Wnt/β-cateninsignal in human melanoma inducesimmunosuppressive and tumorpromoting tumor microenvironment2012

    • Author(s)
      Yaguchi T
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20120919-21
  • [Presentation] 悪性黒色腫に異所性に発現するHistatin-1はin vivoで細胞運動能と免疫抑制能を亢進させる2012

    • Author(s)
      谷口智憲
    • Organizer
      第16回日本がん免疫学会
    • Place of Presentation
      札幌
    • Year and Date
      20120726-28
  • [Presentation] Novel mouse models foranalysis of in vivo interaction ofimmune system and human cancer2011

    • Author(s)
      Yaguchi T
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉(招待講演)
    • Year and Date
      20111127-29
  • [Presentation] The ImmunosuppressiveRole of WNT/beta-catenin signals inmelanoma cancer microenvironments2011

    • Author(s)
      Yaguchi T
    • Organizer
      26th Annual Meeting Society forImmunotherapy of Cancer
    • Place of Presentation
      North Bethesda,Maryland USA
    • Year and Date
      20111104-06
  • [Presentation] Analysis of humanimmune responses using newlydeveloped murine MHC class I andII-deficient NOG mice by humanPBMC inoculation2011

    • Author(s)
      Yaguchi T
    • Organizer
      3rd International Workshop onHUMANIZED MICE
    • Place of Presentation
      Pittsburgh,Pennsylvania USA
    • Year and Date
      20111028-31
  • [Presentation] 悪性黒色腫で異所性に発現するHistatin-1は細胞運動能と免疫抑制能を亢進させる2011

    • Author(s)
      谷口智憲
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20111003-05
  • [Presentation] 悪性黒色腫に異所性に発現するHistatin-1は細胞運動能と免疫抑制能を亢進させる2011

    • Author(s)
      谷口智憲
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      20110630-0701
  • [Patent(Industrial Property Rights)] MMの診断マーカー、ヒスタチン-1タンパク質の機能抑制物質を含有する医薬組成物、および、免疫抑制剤2011

    • Inventor(s)
      谷口智憲 河上裕
    • Industrial Property Rights Holder
      谷口智憲 河上裕
    • Industrial Property Number
      PCT/JP2011/068702
    • Filing Date
      2011-08-18

URL: 

Published: 2014-09-25  

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