Role of desmosomal proteins in skin cancer formation, progression and metastasis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791300
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kurume University
• Principal Investigator: TEYE Kwesi 久留米大学, 医学部, 研究員 (30599303)
• Project Period (FY): 2011 – 2012
• Keywords: 皮膚腫瘍学 / 基底細胞癌 / 有棘細胞癌 / 悪性黒色腫 / デスモゾーム / デスモグレイン / デスモコリン / 皮膚癌治療

Research Abstract

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were investigated immunohistochemically for expression of desmosomal proteins. Poorly-differentiated SCC revealed weak positivity for desmocollin 2 and 3, while well-differentiated SCC and BCC revealed strong positivity for them. These results suggested that desmocollin 2 and 3 might play a role in recurrence and metastasis of skin cancer. SCC and BCC also showedstrong positivity for desmoglein 2 and 3.

Research Products

• [Journal Article] Concurrence of bullous pemphigoid and herpetiform pemphigus with igg antibodies to desmogleins1/3 and desmocollins 1-3. (2012)
  • Author(s): Ohata C, Koga H, Teye K, Ishii N, Hamada T, Dainichi T, Furumura M, Sato M, Sueki H, Hashimoto T.
  • Journal Title: Br J Dermatol Volume: 168(4) Pages: 879-8
  • DOI: 10.1111/bjd.12019
  • Peer Reviewed
• [Journal Article] How do keratinizing disorders and blistering disorders overlap (2012)
  • Author(s): Hamada T, Tsuruta D, Fukuda S, Ishii N, Teye K, Numata S, Dainichi T, KarashimaT, Ohata C, Furumura M, Hashimoto T.
  • Journal Title: Exp Dermatol Volume: 22(2) Pages: 83-7
  • DOI: 10.1111/exd.12021. PMID: 23039137
  • Peer Reviewed
• [Journal Article] Novel ATP-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma. (2011)
  • Author(s): Fukuda S, Hamada T, Ishii N, Sakaguchi S, Sakai K, Akiyama M, Shimizu H, Masuda K, Izu K, Teye K, Tsuruta D, Karashima T, Nakama T, Yasumoto S, Hashimoto T.
  • Journal Title: Br J Dermatol Volume: 166(1) Pages: 218-221
  • DOI: doi:10.1111/j.1365-2133.2011.10516.x.
  • Peer Reviewed
• [Presentation] Newly developed IgA ELISAs of eukaryotic recombinant proteins of desmocollins 1-3 are more sensitive and specific than baculoprotein ELISAs (2012)
  • Author(s): Teye K, Ishii N, Koga H, Hamada T, Karashima T, Numata S, Ohata C, Furumura, M, Hashimoto T.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology.
  • Place of Presentation: Okinawa
  • Year and Date: 20121207-1209
• [Presentation] Takashi HashimotoNewly developed enzyme-linked immunosorbent assays using eukaryotic recombinant proteins of desmocollins (Dsc) are highly sensitive and revealed Dsc2 and Dsc3 as autoantigens specific for paraneoplastic pemphigus (2012)
  • Author(s): Norito Ishii, Shunpei Fukuda, Kwesi Teye, Atsunari Tsuchisaka, Takahiro Hamada, Daisuke Tsuruta, Teruki Dainichi
  • Organizer: The 2012 Society for InvestigativeDermatology Annual Meeting.
  • Place of Presentation: North Carolina (USA)
  • Year and Date: 20120509-0512
• [Presentation] HashimotoGlobal gene expression analysis ofcultured keratinocytes from Hailey-Hailey disease (2012)
  • Author(s): Tadashi Mitsuhiro Matsuda, Takahiro Hamada, Norito Ishii, Kwesi Teye, Atsunari Tsuchisaka, Karashima, Chika Ohata, Minao Furumura, Takashi
  • Organizer: 第26回表皮細胞研究会
  • Place of Presentation: 長野市
  • Year and Date: 2012-11-03