2012 Fiscal Year Final Research Report
Pharmacogenomics of impaired glucose metabolism induced by olanzapine
| Project/Area Number |
23791314
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
FUKUI Naoki 新潟大学, 医歯学系, 助教 (90535163)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗精神病薬 / 糖代謝異常 / 薬理ゲノム学 |
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| Research Abstract |
Meta-analysis of genome-wide association studies (GWAS) have detected several genetic markers related with type 2 diabetes and insulin / glucose levels after an oral glucose challenge. We have examined relationships between these genetic markers and metabolic abnormalities such as the impaired glucose metabolism and obesity, induced by olanzapine and other antipsychotics. Consequently, we found that, I) the relationship between glucose-dependent insulinotropic polypeptide receptor (GIPR) gene and insulin levels after an oral glucose challenge, II) the relationship between GIPR gene and weight gain induced by olanzapine medication, III ) glucose-dependent insulinotropic polypeptide (GIP) gene and BMI / waist circumference.
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