The role of the nucleus accumbens in deficit of decision making: a rodent study with the manipulations on dopamine tone

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: IGUCHI Yoshio 金沢大学, 医学系, 助教 (20452097)
• Project Period (FY): 2011 – 2012
• Keywords: 意思決定 / 習慣形成 / モチベーション / 側坐核 / ドパミントーン / 興奮性シナプス伝達 / 個体差 / ストレス

Research Abstract

Our results suggested that a high-dose administration of a dopamine-receptor partial agonist, aripiprazole, which is thought to block dopamine tone in the nucleus accumbens, would be able to normalize the upregulated excitatory synaptic transmission induced by chronic unpredictable stress or chronic administration of an antidepressant, fluoxetine. In addition, we established a new behavioral measure to reflect motivation, which would depend on dopamine tone in the nucleusaccumbens, and flexible decision making, which would depend on glutamate tone. These resultsprovided clues to understand unknown accumbal role and molecular mechanisms in decision makingand its deficits.

Research Products

• [Presentation] Cocaine differently affects Redox status in the rats nucleus accumbens and dorsal striatum. (2012)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場, 愛知
  • Year and Date: 20120918-21
• [Presentation] The relevance of glutamate- and glutathione-homeostasis in decision-making and cocaine addiction. Neural mechanism for reward-based decision making (2012)
  • Author(s): Toda, S., Kosugi, S., Iguchi, Y., & Minabe, Y
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場, 愛知
  • Year and Date: 20120918-21
• [Presentation] Upregulation of extrasynaptic GABAA receptors in the nucleus accumbens may be responsible for animal model of major depressive disorder (2011)
  • Author(s): Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
  • Organizer: Neuroscience 2011 (SfN's 41th annual meeting)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20111112-16
• [Presentation] Glutamate-independent effects of N-acetylcysteine in synaptic protein turnover in the rat nucleus accumbens after repeated cocaine administration (2011)
  • Author(s): Kosugi, S., Iguchi, Y., Minabe, Y., & Toda, S
  • Organizer: Neuroscience 2011 (SfN's 41th annual meeting)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20111112-16
• [Presentation] Dopamine antagonist induced reduction in PSD proteins in the rat nucleus accumbens after repeated cocaine administration (2011)
  • Author(s): oda, S., Kosugi, S., Iguchi, Y., & Minabe, Y
  • Organizer: Neuroscience 2011 (SfN's 41th annual meeting)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20111112-16
• [Presentation] Upregulation of extrasynaptic GABA^ receptors in the rat nucleus accumbens after repeated unpredictable stress: a possible compensatory mechanism against depression (2011)
  • Author(s): Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
  • Organizer: The Anxiety and Depression: 21st Neuropharmacology Conference
  • Place of Presentation: Falls Church, VA, DC, USA
  • Year and Date: 20111110-11
• [Presentation] pregulation of extrasynaptic GABAA receptors and PSD-95 in the nucleus accumbens may be responsible for animal model of major depressive disorder (2011)
  • Author(s): Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
  • Organizer: 第32回内藤コンファランス「こころの機能と疾患の分子機構」
  • Place of Presentation: 八ヶ岳ロイヤルホテル, 山梨
  • Year and Date: 20111018-21
• [Presentation] Dopamine antagonist induced-PSD protein reductions in the rat nucleus accumbens of after repeated cocaine administration (2011)
  • Author(s): Kosugi, S., Iguchi, Y., Minabe, Y., & Toda, S
  • Organizer: 第32回内藤コンファランス「こころの機能と疾患の分子機構」
  • Place of Presentation: 八ヶ岳ロイヤルホテル, 山梨
  • Year and Date: 20111018-21
• [Presentation] Upregulation of extrasynaptic GABAA receptors and PSD-95 in the nucleus accumbens may be responsible for animal model of major depressive disorder (2011)
  • Author(s): Iguchi, Y., Kosugi, S., Hirosawa, T., Minabe, Y., & Toda, S
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜, 神奈川
  • Year and Date: 20110914-17
• [Presentation] Glutamate-independent effects of N-acetylcysteine in synaptic protein turnover in the rat nucleus accumbens after repeated cocaine administration (2011)
  • Author(s): Kosugi, S., Iguchi, Y., Minabe, Y., & Toda, S
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜, 神奈川
  • Year and Date: 20110914-17
• [Presentation] Dopamine antagonist induced-PSD protein reductions in the rat nucleus accumbens of after repeated cocaine administration (2011)
  • Author(s): Toda, S., Kosugi, S., Iguchi, Y., & Minave, Y
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜, 神奈川
  • Year and Date: 20110914-17
• [Presentation] How do drugs of addiction alter the neuronal functions in the rat nucleus accumbens?: implications of oxidative stress. Gordon Research Conference (2011)
  • Author(s): Toda, S., Kosuig, S., Iguc h i , Y., & Min a b e , Y
  • Organizer: Cathecolamine
  • Place of Presentation: Bates College, Maine, USA
  • Year and Date: 2011-08-10
• [Presentation] 側坐核シナプス外GABA^受容体:大うつ病動物モデルにおける治療標的性の検討
  • Author(s): 井口善生・小杉桜子・廣澤徹・三邉義雄・戸田重誠
  • Organizer: 第20回海馬と高次脳機能学会
  • Place of Presentation: 湯涌創作の森, 石川.
  • Year and Date: 00001008-09
• [Book] インセンティブ,S-R連合,S-S連合他17語 上田恵介・菊水健史他(編) 行動生物学辞典
  • Author(s): 井口善生
  • Publisher: 東京化学同人 (分担執筆)(in press)