2012 Fiscal Year Final Research Report
Clinical study of novel treatment for drug-inducedhyperprolactinemia
| Project/Area Number |
23791318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / 薬剤性高プロラクチン血症 / pramipexole |
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| Research Abstract |
This pilot study aimed to evaluate the efficacy and tolerability of a low dose of pramipexole, a preferential dopamine D3 receptor agonist, in the treatment of antipsychotics -induced hyperprolactinemia. Forty male patients with schizophrenia who were showing hyperprolactinemia were selected. A few subjects are under treatment withadjunctive low-dosage pramipexole. We reported one of the cases who showed risperidone-induced hyperprolactinemia and ED, each of which was improved successfully without any adverse effect such as worsening psychosis.
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