2012 Fiscal Year Final Research Report
The development of novel schizophrenia animal models based on the clinical findings
| Project/Area Number |
23791325
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Meijo University (2012)
Nagoya University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / グルタミン酸作動性神経系低下仮説 / Two-hit 仮説 / 発症機序解明 / 動物モデル / 精神疾患 |
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| Research Abstract |
According to schizophrenia hypothesis, the combined factors in the pathogenesis/pathophyisiology of schizophrenia leads to behavioral abnormalities, which are associated with protein expression in the brain. Environmental enrichment prevents behavioral abnormalities induced by the pathogenesis factor of schizophrenia, which are associated with epigenetic changes in the brain. Appropriate behavioral approaches with such models would be invaluable for providing new insights into the pathogenesis/pathophyisiology of schizophrenia.
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[Journal Article] Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex.2012
Author(s)
Toriumi K, Mouri A, Narusawa S, Aoyama Y, Ikawa N, Lu L, Nagai T, Mamiya T, Kim HC, Nabeshima T.
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Journal Title
Neuropsychopharmacology
Volume: 37
Pages: 1387-96
DOI
Peer Reviewed
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