Connectivity analysis for neural basis of decision-making process and symptoms of schizophrenia

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791329
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: MIYATA Jun 京都大学, 医学(系)研究科(研究院), 助教 (90549099)
• Project Period (FY): 2011 – 2013
• Keywords: 統合失調症 / connectivity / 意思決定 / 拡散テンソル画像 / Surface-based approach / トラクトグラフィ

Research Abstract

Neural basis of decision-making process and symptoms of schizophrenia was investigated by means of connectivity analysis. First, global association between cortical thinning and white matter integrity reduction was found in Schizophrenia. Next, in the pathway between thalamus and orbitofrontal cortex, which is deeply involved in decision-making, reduced white matter integrity was associated with cortical thinning in schizophrenia. Finally, correlation between regional gray matter reduction and subjective quality of life was revealed in schizophrenia.

Research Products

• [Journal Article] Global Association Between Cortical Thinning and White Matter Integrity Reduction in Schizophrenia (2014)
  • Author(s): Sasamoto A, Miyata J, Kubota M, Hirao K, Kawada R, Fujimoto S, Tanaka Y, Hazama M, Sugihara G, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Schizophrenia Bulletin Volume: 40(2) Pages: 420-427
  • DOI: 10.1093/schbul/sbt030
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia (2014)
  • Author(s): Fujino J, Takahashi H, Miyata J, Sugihara G, Kubota M, Sasamoto A, Fujiwara H, Aso T, Fukuyama H, Murai T.
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 48 Pages: 117-123
  • DOI: 10.1016/j.pnpbp.2013.09.018
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia (2013)
  • Author(s): Kubota M, Miyata J, Sasamoto A, Sugihara G, Yoshida H, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: JAMA psychiatry Volume: 70(1) Pages: 12-21
  • DOI: 10.1001/archgenpsychiatry.2012.1023
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia (2013)
  • Author(s): Ubukata S, Miyata J, Yoshizumi M, Uwatoko T, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Journal of Psychiatric Research Volume: 47(4) Pages: 548-554
  • DOI: 10.1016/j.jpsychires.2013.01.002
• [Presentation] 統合失調症における思考の柔軟性-認知的完結欲求と安静時脳活動の相関 (2014)
  • Author(s): 磯部昌憲、宮田淳、横山如人、森康生、杉原玄一、村井俊哉、高橋英彦
  • Organizer: 第9回日本統合失調症学会
  • Place of Presentation: 京都
  • Year and Date: 20140314-15
• [Remarks] プレスリリース
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120904_1.htm