Differential expression of CRF and its stress-related genes in the postmortem brains of suicide victims

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791333
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kobe University
• Principal Investigator: HISHIMOTO Akitoyo 神戸大学, 大学院・医学研究科, 講師 (50529526)
• Project Period (FY): 2011 – 2012
• Keywords: 臨床精神分子遺伝学

Research Abstract

We explored the differential expression of stress-related genes in the postmortem brains of suicide victims and conducted genetic associations of the candidate genes of suicide and schizophrenia. Although we found no evidence of expression difference of stress-related genes such as CRH, we found significant reduced expression of BDNF and DISC1 immunoreactivity in the suicide victims. In addition, we found significant genetic association of DISC1 and EP1 with suicide and schizophrenia. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.

Research Products

• [Journal Article] A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients (2013)
  • Author(s): Supriyanto I, Watanabe Y, Mouri K,Shiroiwa K, Ratta-Apha W, Yoshida M,Tamiya G, Sasada T,Eguchi N , Okazaki K,Shirakawa O, Someya T,Hishimoto A (correspondent)
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 40 Pages: 347-52
  • DOI: DOI:10.1016/j.pnpbp.2012.11.002.
  • Peer Reviewed
• [Journal Article] 全般性不安障害を合併した大うつ病性障害にエスシタロプラムの付加療法が著効した一例 (2013)
  • Author(s): 菱本明豊,荒賀哲也,田中究
  • Journal Title: 臨床精神薬理誌 Volume: Vol.16 No.2 Pages: 237-243
  • Peer Reviewed
• [Journal Article] NrCAM-regulating neural systems and addiction-related behaaddiciors. (2012)
  • Author(s): Ishiguro H, Hall FS, Horiuchi Y, Sakurai T, Hishimoto A,Grumet M, Uhl GR, Onaivi ES, Arinami T
  • Journal Title: Addict Biol Volume: (Epub ahead of print)
  • DOI: DOI:10.1111/j.1369-1600.2012.00469.x.
  • Peer Reviewed
• [Journal Article] Haplotypes in the expression quantitative trait locus of interleukin-1β gene are -91. 10.1016/j.schres.2012.06.031. associated with schizophrenia (2012)
  • Author(s): Yoshida M, Shiroiwa K, Mouri K, Ishiguro H, Supriyanto I, Ratta-Apha W, Eguchi N, Okazaki S, Sasada T, Fukutake M, Hashimoto T, Inada T, Arinami T, ShO, Hishimoto A (correspondent)
  • Journal Title: Schizophr Res Volume: 140(1-3) Pages: 185-91
  • DOI: DOI:10.1016/j.schres.2012.06.031.
  • Peer Reviewed
• [Journal Article] NrCAM-regulating neural systems and addiction-related behaviors (2012)
  • Author(s): Ishiguro H, Hall FS, Horiuchi Y,Sakurai T, Hishimoto A,Grumet M, Uhl GR,Onaivi ES, Arinami T.
  • Journal Title: Addict Biol
  • DOI: DOI:10.1111/j.1369-1600.2012.00469.x.
  • Peer Reviewed
• [Journal Article] Alexithymia and its relationships with eating behavior, self esteem, and body esteem in college women (2011)
  • Author(s): Sasai K,Tanaka K, Hishimoto A (correspondent)
  • Journal Title: Kobe J Med Sci Volume: 56(6) Pages: E231-8
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21937871
  • Peer Reviewed
• [Journal Article] Association study of EP1 gene polymorphisms with suicide completers in the Japanese population (2011)
  • Author(s): Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y Hishimoto A , (corresponden)
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 35(4) Pages: 1108-11
  • DOI: DOI:10.1016/j.pnpbp.2011.03.010.
  • Peer Reviewed
• [Journal Article] Association study of BDNF with completed suicide in the Japanese population.
  • Author(s): Ratta-apha W, Hishimoto A(correspondent), Yoshida M, Ueno Y, Asano M, Shirakawa O, Sora I
  • Journal Title: Psychiatry Research Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] 般身体科領域において投与されたMirtazapineの後方視的調査-せん妄との関連を中心に
  • Author(s): 白岩恭一, 田中究, 大本暢子, 平井みどり, 菱本明豊
  • Journal Title: 精神医学 Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Haplotypes in the expression quantitative trait locus of in erleukin-1β gene are associated with schizophrenia (2012)
  • Author(s): Yoshida M, Mouri K, Hishimoto A
  • Organizer: ASHG
  • Place of Presentation: San Francisco
  • Year and Date: 20121106-10
• [Presentation] ALCOHOL AND ALDEHYDE DEHYDROGENASE POLYMORPHISMS AND RISK FOR SUICIDE (2012)
  • Author(s): Hishimoto A.
  • Organizer: ISBRA
  • Place of Presentation: Hokkaido
  • Year and Date: 20120709-11
• [Presentation] The Use of Aripiprazole in Serotonin Reuptake I bitor Resis t Obsessive-Compulsive Disorder: A Naturalistic, Retrospective Case Study for 24 Patients (2012)
  • Author(s): Hishimoto A
  • Organizer: CINP annual meeting
  • Place of Presentation: Stockholm
  • Year and Date: 20120605-09
• [Presentation] Associ ion st y of EP1 gene polymorphisms with suicide completers in the Japan se opulation (2011)
  • Author(s): Hishimoto A
  • Organizer: 10th World Congress of Biological Psychitary
  • Place of Presentation: Prague
  • Year and Date: 2011-05-06
• [Book] 精神疾患診断のための脳形態・機能検査法 (2012)
  • Author(s): 三國雅彦・福田正人・功刀浩
  • Total Pages: 350
  • Publisher: 新興医学出版社
• [Book] 『専門医のための精神科臨床リュミエール29』自殺予防の基本戦略(張賢徳編)「自殺の生物学的知見」 (2011)
  • Author(s): 福武将映, 菱本明豊,白川治
  • Total Pages: 300
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/psyneu/newfolder1/index.html