2012 Fiscal Year Final Research Report
A study of new drug development of target of histone deacetylase
| Project/Area Number |
23791336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
OTUKI Kouji 山口大学, 大学院・医学系研究科, 助教 (10535256)
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| Project Period (FY) |
2011 – 2012
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| Keywords | GDNF / HDAC4 |
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| Research Abstract |
Interestingly, HDAC4 significantly inhibited the induction of GDNF mRNA by antidepressants. Therefore the level of phosphorylation of HDAC4 was increased by antidepressants. In the animal syudy, mutant HDAC4 was suggested that antidepressant effect.
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[Journal Article] Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 12011
Author(s)
Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, & Watanabe Y
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 108
Pages: 1681-1686
Peer Reviewed
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