2012 Fiscal Year Final Research Report
Biological diagnostic test for major depressive disorder based on the leukocytes gene expression
| Project/Area Number |
23791337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IGA Jun-ichi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (70363140)
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| Project Period (FY) |
2011 – 2012
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| Keywords | うつ病 / 白血球 / 遺伝子発現 / バイオマーカー |
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| Research Abstract |
[Introduction] The goal of present work was to test the performance of a composite, multi-assay diagnostic test for MDD based on the leukocyte gene expression profiles. [Methods] 25 patients, who met criteria for MDD were eligible for enrollment in this study. 25 non-depressed healthy individuals toserve as a control group were recruited from Tokushima University Hospital. We examined the levels of 40 gene expressions simultaneously using custom-made PCR plate. [Results] 13 gene expressions were significantly changed in MDD. MDD score demonstrated a sensitivity and specificity of 72% and 84%, respectively, in differentiating between MDD patients and healthy subjects. [Discussion] Further research is needed to confirm the performance of the test in other independent samples of patients.
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[Journal Article] Depression in X-linked dystonia-parkinsonism: A case-control study.2013
Author(s)
Morigaki R, Nakataki M, Kawarai T, Lee LV, Teleg RA, Tabuena MD, Mure H, Sako W, Pasco PM, Nagahiro S, Iga J, Ohmori T, Goto S, Kaji R
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Journal Title
Parkinsonism Relat Disord
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[Journal Article] DNA methylation signatures of peripheral leukocytes in schizophrenia2013
Author(s)
Kinoshita M, Numata S, Tajima A, Shimodera S, Ono S, Imamura A, Iga J, Watanabe S, Kikuchi K, Kubo H, Nakataki M, Sumitani S, Imoto I, Okazaki Y, Ohmori T
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Journal Title
Neuromolecular Med
Volume: 15
Pages: 95-101
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