Optimization of the therapeutic protocol of the repetitive transcranial magnetic stimulation (rTMS) to mood disorder and investigation of the rTMS-induced neuroplasticity.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791345
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Yokohama City University
• Principal Investigator: NAKAMURA Motoaki 横浜市立大学, 医学研究科, 客員研究員 (50464532)
• Research Collaborator: NODA Yoshihiro 東京大学, 医学研究科, 大学院生 ; SAEKI Takashi 横浜市立大学, 医学研究科, 大学院生 ; HAYASAKA Shyunsuke 横浜市立大学, 医学研究科, 大学院生 ; TSUCHIYA Yoshie 横浜市立大学, 医学部, 医局員 ; IZUNO Takuji 昭和大学, 医学部, 医局員
• Project Period (FY): 2011 – 2012
• Keywords: 経頭蓋磁気刺激法 / 気分障害 / 背外側前頭前野 / 脳画像 / 脳波 / 神経可塑性

Research Abstract

We have established a randomized controlled trial (RCT) protocol of repetitive transcranial magnetic stimulation (rTMS) for the medication-resistant patients with major depression, controlled with a sophisticated sham rTMS system. The present RCT design could make it possible to compare different rTMS protocols directly during the acute phase and to examine a prophylactic effect of rTMS during the maintenance phase. As this RCT has not been completed so far, the final analyses, including neurobiological changes induced by consecutive rTMS sessions, are going to be done after the RCT completion.

Research Products

• [Journal Article] Potentiation on quantitative electroencephalograms following Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients with Major Depression (2013)
  • Author(s): Noda Y, Nakamura M, Takashi Saeki T, Inoue M, Iwanari H, Kasai K
  • Journal Title: Neuroscience Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] Localized potentiation of sleep slow-wave activity induced by prefrontal repetitive transcranial magnetic stimulation in patients with a major depressive episode (2013)
  • Author(s): Saeki T, Nakamura M, Hirai N, Noda Y, Hayasaka S, Iwanari H, Hirayasu Y
  • Journal Title: Brain stimulation Volume: 6(3) Pages: 390-6
  • Peer Reviewed
• [Journal Article] Neuromodulation in clinical psychiatry; its history, present, and future (2012)
  • Author(s): Nakamura M
  • Journal Title: Japanese Journal of Biological Psychiatry Volume: 23(2) Pages: 121-129
  • Peer Reviewed
• [Journal Article] Therapeutic Application of Repetitive Transcranial Magnetic Stimulation for Major Depression (2012)
  • Author(s): Nakamura M
  • Journal Title: Seishin Shinkeigaku Zasshi Volume: 114(11) Pages: 1131-1149
  • Peer Reviewed
• [Journal Article] Therapeutic application of repetitive transcranial magnetic stimulation (rTMS) to major depression (2011)
  • Author(s): Nakamura M
  • Journal Title: Japanese Journal of Biological Psychiatry Volume: 22(3) Pages: 181-189
  • Peer Reviewed
• [Presentation] 「rTMS の科学的基盤」 トピックフォーラム 17「うつ病に対するrTMS治療の有効な臨床応用にむけて」 (2013)
  • Author(s): 中村 元昭
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2013-05-25
• [Presentation] 「rTMS の有効性を高める」 シンポジウム 29 「ECTの進歩と rTMSへの期待」 (2013)
  • Author(s): 中村 元昭
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2013-05-24
• [Presentation] 「rTMS の作用機序-主に脳形態画像と脳波の側面から-」 シンポジウム 8「電気けいれん療法・磁気刺激療法の生物学的基盤」 (2012)
  • Author(s): 中村 元昭
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-09-28
• [Presentation] Biology of rTMS: structural and electrophysiological brain alterations induced by rTMS possibly associated with its antidepressant effect (2011)
  • Author(s): Nakamura M
  • Organizer: Symposium Presentation at World Congress of Asian Psychiatry (WCAP)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2011-08-02
• [Presentation] Navigation-guided repetitive transcranial magnetic stimulation (rTMS) applied to major depression and rTMS-induced structural brain alterations (2011)
  • Author(s): Nakamura M, Noda Y, Saeki T, Kawamoto E, Nagafusa Y, Inoue M, Yamamoto Y, Iwama H, Iwanari H, and Hirayasu Y
  • Organizer: Oral Presentation at 10th World Congress of Biological Psychiatry (WFSBP)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2011-06-02
• [Book] 【経頭蓋磁気刺激の臨床、研究への応用】うつ病治療への応用 (2013)
  • Author(s): 中村 元昭
• [Book] うつ病(分担) (2012)
  • Author(s): 中村 元昭
  • Publisher: 精神保健 福祉白書(2013 年版)
• [Book] 遺伝子多型(COMT、BDNF、NRGI)と脳構造・脳機能(神経画像遺伝学) (2011)
  • Author(s): 中村 元昭
  • Publisher: 星和書店
• [Book] DTI (Diffusion Tensor Imaging) (分担) (2011)
  • Author(s): 中村 元昭
  • Publisher: 精神科臨床評価検査法マニュアル. 「臨床精神医学」編集委員会(編集).アークメディア
• [Remarks]
  • URL: http://www.kinkou.org/rTMS.html
• [Remarks] 当該研究の取り組みの一部が 2012 年 2 月 12日の NHK スペシャル「ここまで来た!うつ病治療」において紹介された。
  • URL: http://www.nhk.or.jp/special/onair/120212.html
• [Remarks] 同ドキュメンタリー番組は書籍化され、以下の書籍の中でも当該研究での成果の一部が紹介されている。
• [Remarks] NHK取材班: NHKスペシャル ここまで来た!うつ病治療 宝島社,2012