2012 Fiscal Year Final Research Report
Neural background of dysfunction in social cognition among patients with Alzheimer's disease
| Project/Area Number |
23791354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
TSUNO Norifumi 東京慈恵会医科大学, 医学部, 講師 (20317978)
NAGATA Tomoyuki 東京慈恵会医科大学, 医学部, 助教 (00408428)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アルツハイマー病 / 認知症 / 社会認知 / 精神症状 / 不安 / 神経基盤 |
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| Research Abstract |
In the present study, we aimed to elucidate neural correlates of social cognition and behavioral symptom which is characteristic to patients withAlzheimer’s disease with using neuropsychological assessment tools and morphologic / functional neuroimaging methods. In neuroimaging, appearance of anxiety inAlzheimer’s disease was correlated to atrophy in right precunei and hyperperfusion in bilateral anterior cingulate cortices. These correlations persisted when age at onset and affective score was included as a covariate. These results suggest that appearance of anxiety and dysfunction in social cognition in Alzheimer’s disease might associate with these brain areas.
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