2012 Fiscal Year Final Research Report
Genome-Wide association study of atypical psychisis
| Project/Area Number |
23791356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 非定型精神病 / 臨床診断基準 / GWAS |
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| Research Abstract |
The most significant SNPs were detected around the CHN2/CPVL genes (rs245914, p=1.6×10-7), COL21A1 gene (rs12196860, p=2.45×10-7), and PYGL/TRIM9 genes (rs1959536, p=7.73×10-7), although none of the single-nucleotide polymorphisms exhibited genome-wide significance (p=5×10-8). One of the highest peaks was detected on the major histocompatibility complex region, where large SZ GWASs have previouslydisclosed an association. The gene-based analysis suggested significant enrichment between SZ and atypical psychosis (p=0.01), but not BD. CONCLUSIONS: This study provides clues about the types of patient whose diagnosis lies between SZ and BD. Studies with larger samples are required to determine the causal variant.
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