Identification of mitochondrial dysfunction and genetic analysis of mtDNA in schizophrenia patients

2013 Fiscal Year Final Research Report

• Project/Area Number: 23791367
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Meiji Pharmaceutical University (2013); Tokyo Metropolitan Institute of Medical Science (2011-2012)
• Principal Investigator: ICHIKAWA Tomoe 明治薬科大学, 薬学部, 助教 (60383288)
• Project Period (FY): 2011 – 2013
• Keywords: 統合失調症 / ミトコンドリアDNA

Research Abstract

We searched for distinctive non-synonymous, and rare tRNA variants in mtDNA. Several rare variants were detected in Japanese schizophrenia samples but not in controls. Furthermore, rare variants were identified in five of eight cases showing increased mtDNA copy number.

Research Products

• [Journal Article] Schizophrenia : maternal inheritance and heteroplasmy of mtDNA mutations (2012)
  • Author(s): Ichikawa T, Arai M, Miyashita M, Arai M, Obata N, Nohara I, Oshima K, Niizato K, Okazaki Y, Doi N, Itokawa M.
  • Journal Title: Molecular Genetics and Metabolism 105 Volume: 105 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Paradox of schizophrenia genetics : is a paradigm shift ocurring? (2012)
  • Author(s): Doi N, Hoshi Y, Itokawa M, Yoshikawa T, Ichikawa T, Arai M, Usui C, Tachikawa H.
  • Journal Title: Behav Brain Func Volume: 8(1) Pages: 28
  • Peer Reviewed
• [Presentation] 統合失調症患者に特徴的なミトコンドリアDNAのrare variantの探索 (2013)
  • Author(s): 市川智恵、新井誠、宮下光弘、鳥海和也、新井麻友美、小幡奈々子、野原泉、小堀晶子、大島健一、新里和弘、岡崎祐士、土井永史、糸川昌成
  • Organizer: 第8回日本統合失調症学会
  • Place of Presentation: 浦河町総合文化会館(北海道)
  • Year and Date: 20130419-20
• [Presentation] 統合失調症患者のミトコンドリアDNAにおけるrare variantの探索 (2012)
  • Author(s): 市川智恵、新井誠、宮下光弘、新井麻友美、小幡菜々子、野原泉、大島健一、新里和弘、岡崎祐士、土井永史、糸川昌成
  • Organizer: 第35回日本分子生物学学会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 20121211-14
• [Presentation] 統合失調症患者に特徴的なミトコンドリアDNAの多型・変異の探索 (2012)
  • Author(s): 市川智恵、新井誠、宮下光弘、新井麻友美、小幡菜々子、野原泉、大島健一、新里和弘、岡崎祐士、土井永史、糸川昌成
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 20120928-30
• [Presentation] Impact of Epidemiology on Molecular Genetics of Schizophrenia. II. Mitochondrial DNA Hypothesis for Schizophrenia (2012)
  • Author(s): Nagafumi Doi, Yoko Hoshi, Masanari Itokawa, Takeo Yoshikawa,Tomoe Ichikawa, Makoto Arai, Chie Usui, Hirokazu Tachikawa
  • Organizer: Paulo International Medical Symposium 2012 entitled Schizophrenia-Epidemiology and Biology
  • Place of Presentation: フィンランド
  • Year and Date: 20120928-30
• [Presentation] 統合失調症患者末梢血におけるミトコンドリアDNAの遺伝子解析 (2012)
  • Author(s): 市川智恵,新井誠,宮下光弘,新井麻友美,野原泉,小幡菜々子,大島健一,新里和弘,岡崎祐士,土井永史,糸川昌成
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 愛知県産業労働センター(愛知)
  • Year and Date: 2012-03-16
• [Presentation] 統合失調症患者由来ミトコンドリアDNAの遺伝子解析 (2011)
  • Author(s): 市川智恵、新井誠、宮下光弘、野原泉、小幡菜々子、新井麻友美、田中陽子、大島健一、新里和弘、岡崎祐士、土井永史、糸川昌成
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-18
• [Presentation] 統合失調症患者におけるミトコンドリアDNAの遺伝子解析 (2011)
  • Author(s): 市川智恵、新井誠、宮下光弘、野原泉、小幡菜々子、新井麻友美、田中陽子、大島健一、新里和弘、岡崎祐士、土井永史、糸川昌成
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: グランパシフィックLE DAIBA(東京)
  • Year and Date: 2011-05-22
• [Book] Impact of Epidemiology on Molecular Genetics of Schizophrenia EPIDEMIOLOGY INSIGHTS, Chapter 7 (2012)
  • Author(s): Nagafumi Doi, Yoko Hoshi, Masanari Itokawa, Takeo Yoshikawa and Tomoe Ichikawa
  • Total Pages: 113-138
  • Publisher: Edited by Maria de Lourdes Ribeiro de Souza da Cunha