2013 Fiscal Year Final Research Report
The ABC transporter family in psychiatric diseases
| Project/Area Number |
23791371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJII Takashi 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 科研費研究員 (10450610)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経科学 / 脳神経疾患 / ストレス応答生理 / ABCトランスポーター / 認知機能解析 / 遺伝子解析 / 大うつ病性障害 / 統合失調症 |
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| Research Abstract |
In this study, we focused on ABC transporter family, which might be involved in the pathogenesis of schizophrenia and major depressive disorder (MDD). First, we reported a significant association between the rs2230808 (R1587K) of ABCA1 and schizophrenia in men. In the study of ABCB1 encoding the P-glycoprotein gene, we selected the five functional polymorphisms (A-41G [rs2188524], T-129C [rs3213619], C1236T [rs1128503], G2677A/T [rs2032582], and C3435T [rs1045642]). We found that the minor T3435 allele of rs1045642 was significantly increased in MDD patients than in the controls and homozygotes for the T3435 allele was significantly more common in patients than in the controls. These results suggest that the T3435 allele or carrying two copies of this allele confers susceptibility to MDD in the Japanese population.
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[Journal Article] Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals2014
Author(s)
Hori H, Yamamoto N, Teraishi T, Ota M, Fujii T, Sasayama D, Matsuo J, Kinoshita Y, Hattori K, Nagashima A, Ishida I, Koga N, Higuchi T, Kunugi H.
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Journal Title
J Affect Disord
Pages: 10
DOI
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[Journal Article] Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults2013
Author(s)
Teraishi T, Sasayama D, Hori H, Yamamoto N, Fujii T, Matsuo J, Nagashima A, Kinoshita Y, Hattori K, Ota M, Fujii S, Kunugi H.
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Journal Title
Behav Brain Funct
Volume: 9(1)
Pages: 30
DOI
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[Journal Article] Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals2012
Author(s)
Hori H, Yamamoto N, Fujii T, Teraishi T, Sasayama D, Matsuo J, Kawamoto Y, Kinoshita Y, Ota M, Hattori K, Tatsumi M, Arima K, Kunugi H.
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Journal Title
Sci Rep
Volume: 2
Pages: 634
DOI
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[Journal Article] Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population2012
Author(s)
Fujii T, Ota M, Hori H, Sasayama D, Hattori K, Teraishi T, Yamamoto N, Hashikura M, Tatsumi M, Higuchi T, Kunugi H.
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Journal Title
J Psychiatr Res
Volume: 46(4)
Pages: 555-9
DOI
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[Journal Article] Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorder2011
Author(s)
Fujii T, Yamamoto N, Hori H, Hattori K, Sasayama D, Teraishi T, Hashikura M, Tatsumi M, Okamoto N, Higuchi T, Kunugi H.
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Journal Title
J Hum Genet
Volume: 56(11)
Pages: 806-9
DOI
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[Presentation] Association analysis of the C3435T polymorphism of ABCB1 with major depressive disorder2012
Author(s)
Takashi Fujii, Hiroaki Hori, Miho Ota, Daimei Sasayama, Kotaro Hattori, Toshiya Teraishi, Noriko Yamamoto, Miyako Hashikura, Masahiko Tatsumi, Teruhiko Higuchi, Hiroshi Kunugi
Organizer
第35回日本神経科学会
Place of Presentation
神戸国際会議場
Year and Date
20120918-21
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[Presentation] P糖タンパク質(ABCB1)の機能多型と大うつ病性障害発症脆弱性2012
Author(s)
藤井崇,太田深秀,堀弘明,服部功太郎,篠山大明,寺石俊也,山本宣子,橋倉都,巽雅彦,樋口輝彦,功刀浩
Organizer
第7回トランスポーター研究会
Place of Presentation
京都大学
Year and Date
20120609-10
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[Presentation] The functional polymorphisms of P-glycoprotein (ABCB1) and susceptibility to develop major depressive disorder2011
Author(s)
Fujii T, Ota M, Hori H, Hattori K, Sasayama D, Teraishi T, Hashikura M, Tatsumi M, Okamoto N, Higuchi T, Kunugi H.
Organizer
第34回日本分子生物学会
Place of Presentation
パシフィコ横浜
Year and Date
2011-12-14
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