2012 Fiscal Year Final Research Report
Testing the dimensional model between schizophrenia and schizotypy
| Project/Area Number |
23791372
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
HORI Hiroaki 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第三部, 流動研究員 (10554397)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / 統合失調型パーソナリティ / 臨床 / 認知機能 / 遺伝子多型 |
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| Research Abstract |
By investigating similarities and differences between schizophrenia and schizotypal personality in terms of genes and cognition, this study aimed to provide evidence that contributes to elucidating the pathophysiology of schizophrenia. A series of investigations have revealed that schizotypal traits in healthy individuals and those in patients with mood disorder show a cognitive profile similar to the one seen in schizophrenia and that a genetic polymorphism within CACNA1C, a gene that has been shown to be associated with mood disorders and schizophrenia, affects cognition in schizophrenia.
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