2012 Fiscal Year Final Research Report
The association between sleepiness and cognitive dysfunction and brain micro-morphological change in obstructive sleep apnea syndrome
| Project/Area Number |
23791374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
NAKAMURA Masaki 公益財団法人神経研究所, 研究部, 研究員 (70375054)
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| Project Period (FY) |
2012
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| Keywords | 精神生理学 |
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| Research Abstract |
We measured cognitive and emotional impairment of the patients suffered severe obstructive sleep apnea syndrome(sOSAS), and investigated the correlation between these cognitive and emotional impairment and respiratory index during sleep. Additionally, we applied the voxel-based statistic approach by SPM8-regression for FA/ADC maps and gray/white matter images to estimate the correlation between brain microstructural changes of sOSAS and respiratory index during sleep. As a results, subjective daytime sleepiness was only associated with motivation and only lowest SpO2 affected on cognitive impairment. In imaging study, lowest SpO2 showed positive correlation with medial and inferior frontal area where are important for higher cognitive function and brain-stem containing many nuclei for arousal maintaining function in FA/ADC maps and white matter image. The gray matter concentration in parahippocampal area was also affected positive correlation with lowest SpO2. As a conclusion, lower SpO2 (hypoxia invasion) might cause the cognitive impairment and this impairment would be caused by neural axonal microstructural changes by hypoxia invasion.
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