2012 Fiscal Year Final Research Report
Investigation on the molecular mechanism of increased radioresistance in cancer cells exposed to intermittent hypoxia
| Project/Area Number |
23791375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUI Hironobu 北海道大学, 大学院・獣医学研究科, 助教 (10570228)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 固形腫瘍 / 間欠的低酸素 / 放射線感受性 / 細胞周期 |
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| Research Abstract |
In this study, I revealed the molecular mechanism of intermittent hypoxia-induced rasioresistance in tumor cells as follows;
The preconditioning of tumor cells with intermittent hypoxia increased the radioresistance compared to normoxia and persistent hypoxia.
The treatment of intermittent hypoxia induced the production of reactive oxygen species and the over-expression of the hypoxia inducible factor-1α, suggesting the involvement of cellular redox status and hypoxia-response signal pathway in the biological effect of intermittent hypoxia.
The treatment of intermittent hypoxia decreased the fraction of the relative radiosensitive early S phase and increased that of the radioresistant G2 phase.
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[Journal Article] EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate2013
Author(s)
Matsumoto S., Saito K., Yasui H., Morris H.D., Munasinghe J.P., Lizak M., Merkle H., Ardenkjaer-Larsen J.H., Choudhuri R., Devasahayam N., Subramanian S., Koretsky A.P., Mitchell J.B., and Krishna M.C.
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Journal Title
Magn. Reson. Med
Volume: 69(5)
Pages: 1443-1450
Peer Reviewed
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[Journal Article] Anti-angiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia2011
Author(s)
Matsumoto S., Batra S., Saito K., YasuiH., Choudhuri R., Gadisetti C.,Subramanian S., Devasahayam N., Munasinghe J.P., Mitchell J.B., and Krishna M.C.
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Journal Title
Cancer Res
Volume: 71(20)
Pages: 6350-6359
Peer Reviewed
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[Journal Article] A nucleoside anticancer drug,1-(3-C-ethynyl-β-D-ribo-pentofuranos yl) cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression2011
Author(s)
Meike S., Yamamori T., Yasui H., Eitaki M., Matsuda A., Morimatsu M., Fukushima M., Yamasaki Y., and Inanami O.
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Journal Title
Mol. Cancer
Volume: 10
Pages: 92
Peer Reviewed
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[Presentation] がんの放射線治療効率化に向けたESR技術の適用2012
Author(s)
安井博宣,松元慎吾,伊藤慎治,山盛徹,兵藤文紀,市川和洋,中村秀夫,内海英雄,Krishna M.C.,稲波修
Organizer
第51回電子スピンサイエンス学会年会シンポジウム
Place of Presentation
in札幌コンベンションセンター(札幌市,北海道)
Year and Date
20121101-03
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