Amyloid PET imaging in idiopathic normal-pressure hydrocephalus

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: HIRAOKA Kotaro 東北大学, ラジオアイソトープセンター・サイクロトロン, 助教 (70586049)
• Project Period (FY): 2011 – 2012
• Keywords: 特発性正常圧水頭症 / アミロイドβ蛋白 / PET(陽電子放射断層撮影 )

Research Abstract

Amyloid PET imaging was performed in 5 iNPH (idiopathic normal-pressure hydrocephalus) patients before shunt surgery. The results suggested that there were not so much neocortical amyloid deposits in these cases. We are planning to perform amyloid imaging on more iNPH patients, and verify the usefulness of amyloidimaging in predicting treatment effects of shunt surgery.

Research Products

• [Journal Article] Cholinergic Deficit and Response to Donepezil Therapy in Parkins on's Disease with Dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hay ashi A, Tashiro M, Hisanaga K, Fuji i T, Takeda A, Yanai K, Iwata R, Mo ri E.
  • Journal Title: Eur Neu rol Volume: 68 Pages: 137-143
  • URL: http://www.karger.com/Article/FullText/338774
  • Peer Reviewed
• [Journal Article] [(11)C]Doxepin binding to histamine H1 receptors in living human br ain: reproducibility during attenti ve waking and circadian rhythm (2012)
  • Author(s): Shibuya K, Funaki Y, Hiraoka K, Yos hikawa T, Naganuma F, Miyake M, Watanuki S, Sato H, Tashiro M,Yanai K.
  • Journal Title: Front Syst Neurosci Volume: 6 Pages: 45
  • DOI: doi:10.3389/fnsys.2012.00045.
  • Peer Reviewed
• [Journal Article] Total aortic arch replacement u sing hypothermic circulatory arrest with antegrade selective cerebralperfusion: are there cerebral defic its other than frank stroke? (2012)
  • Author(s): Hiraoka K, Kawatsu S, Mori E, Saiki Y.
  • Journal Title: Gen Th orac Cardiovasc Surg Volume: 60 (6) Pages: 345-9
  • DOI: doi:10.1007/s11748-012-0057-8.
  • Peer Reviewed
• [Journal Article] A Validation Study of the Japanese Version of the Addenbrooke's Cognitive Examination-Revised (2012)
  • Author(s): Dos Santos Kawata KH, Hashimoto R, Nishio Y, Hayashi A, Ogawa N, Kanno S, Hiraoka K, Yokoi K, Iizuka O, M ori E.
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 2(1) Pages: 29-37
  • DOI: doi:10.1159/000336909.
  • Peer Reviewed
• [Journal Article] Counting-backward t est for executive function in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Kanno S, Saito M, Hayashi A, Uchiya ma M, Hiraoka K, Yoshiyuki, N, Hisa naga K, Mori E.
  • Journal Title: Acta Neurol Scand Volume: 126 (4) Pages: 279-86
  • DOI: doi:10.1111/j.1600-0404.2012.01644.x.
  • Peer Reviewed
• [Journal Article] カイロプラクティック施術の神経生理学的影響に関する検討 (2012)
  • Author(s): 小倉毅、田代学、四月朔日聖一、マスッド・メヘディ、渋谷勝彦、稲見暁恵、三宅正泰、平岡宏太良、山口慶一郎、谷内一彦
  • Journal Title: 日本統合医療学会誌 Volume: 5(2) Pages: 1-6
  • URL: http://colors-cp.com/genkou.pdf
  • Peer Reviewed
• [Journal Article] The effects of aging and Alzh eimer's disease on associative reco gnition memory (2011)
  • Author(s): Hanaki R, Abe N, Fujii T, Ueno A, Nishio Y, Hiraoka K, Shimomura T, Ii zuka O, Shinohara M, Hirayama K, Mori E.
  • Journal Title: Neurol Sci Volume: 32(6) Pages: 1115-22
  • DOI: doi:10.1007/s10072-011-0748-4.
  • Peer Reviewed
• [Journal Article] White matte r involvement in idiopathic normal pressure hydrocephalus: a voxel-bas ed diffusion tensor imaging study (2011)
  • Author(s): Kanno S, Abe N, Saito M, Takagi M, Nishio Y, Hayashi A, Uchiyama M, Hanaki R, Kikuchi H, Hiraoka K, Yamas aki H, Iizuka O, Takeda A, Itoyama Y, Takahashi S, Mori E.
  • Journal Title: J Neurol Volume: 258(11) Pages: 1949-57
  • DOI: doi:10.1007/s00415-011-6038-5.
  • Peer Reviewed
• [Journal Article] False item recognition in patients with Alzhe imer's disease (2011)
  • Author(s): Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hira oka K, Yamasaki H, Choi H, HirayamaK, Shinohara M, Mori E.
  • Journal Title: Neuropsychologia Volume: 49 (7) Pages: 1897-902
  • DOI: doi:10.1016/j.neuropsychologia.2011.03.015.
  • Peer Reviewed
• [Journal Article] Is the midb rain involved in the manifestation of gait disturbance in idiopathic n ormal-pressure hydrocephalus? (2011)
  • Author(s): Hiraoka K, Yamasaki H, Takagi M, Sa ito M, Nishio Y, Iizuka O, Kanno S, Kikuchi H, and Mori E
  • Journal Title: Journal of Neurology Volume: 258(5) Pages: 820-5
  • DOI: doi:10.1007/s00415-010-5847-2.
  • Peer Reviewed
• [Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Kotaro Hiraoka, Nobuyuki Okamura,Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, and Etsuro Mori
  • Organizer: The JSPS-NRF Asian Science Seminar2012
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20120200
• [Presentation] 11C-doxepinを用いたPETによる抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定 (2012)
  • Author(s): 平岡宏太良、田代学、石渡喜一、石井賢二、谷内一彦
  • Organizer: 第33回日本臨床薬理学会学術総会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-11-29
• [Presentation] Amyloid imaging in iNPH (2012)
  • Author(s): Kotaro Hiraoka, Shigenori Kanno,Hirokazu Kikuchi, Manabu Tashiro, Nobuyuki Okamura, Katsutoshi Furukawa, Hiroyuki Arai, Ren Iwata, Etsuro Mori, Kazuhiko Yanai
  • Organizer: Hydrocephalus 2012
  • Place of Presentation: Kyoto
  • Year and Date: 2012-10-22
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良、菅野重範、菊池大一、田代学、岡村信行、古川勝敏、荒井啓行、岩田錬、森悦朗、谷内一彦
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-12
• [Presentation] 認知症を伴うパーキンソン病におけるコリン神経系の障害とドネペジルによる治療効果 (2012)
  • Author(s): 平岡宏太良、岡村信行、船木善仁、林亜希子、田代学、久永欣哉、藤井俊勝、武田篤、谷内一彦、岩田錬、森悦朗
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良、菅野重範、菊池大一、田代学、岡村信行、古川勝敏、荒井啓行、岩田錬、森悦朗、谷内一彦
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] Cholinergic deficit and response to donepezil therapy inParkinson's disease with dementia: [5-11C-methoxy]donepezil-PET study (2012)
  • Author(s): Kotaro Hiraoka
  • Organizer: 64th AAN Annual Meeting
  • Place of Presentation: New Oreleans, USA
  • Year and Date: 2012-04-25
• [Presentation] Nano-bio-imaging withRadioharmaceuticals and Application to Health Sciences (2012)
  • Author(s): K. Hiraoka
  • Organizer: 18th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre
  • Place of Presentation: Tohoku University
  • Year and Date: 2012-03-05
• [Presentation] iNPHにおける脳内アミロイド蓄積量の計測 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第13回日本正常圧水頭症学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-11
• [Presentation] Changes in the volumes of the brain and cerebrospinal fluid spaces aftershunt surgery in idiopathic normal-pressure hydrocephalus (2011)
  • Author(s): Hiraoka, K., Takagi, M., Saito, M., Nishio, Y., Iizuka, O., Kanno, S., Kikuchi, H., Kondo, T. and Mori, E.
  • Organizer: Hydrocephalus 2011
  • Place of Presentation: Rigshospitalet, Copenhagen, Denmark
  • Year and Date: 20110904-07
• [Presentation] 認知障害を伴うパーキンソン病におけるdonepezilのアセチルコリンエステラーゼに対する結合:[5-11C-methoxy]donepezilを用いたPET研究 (2011)
  • Author(s): 平岡宏太良
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18