2012 Fiscal Year Final Research Report
Study for radiotherapy-induced tumor specific immunity.
| Project/Area Number |
23791393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗腫瘍免疫 / 放射線治療 / 癌精巣抗原 |
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| Research Abstract |
The aim of this study is to examine weather a radiation therapy can induce specific anti-tumor immunity in human cancer patients. ELISPOT assay revealed that tumor specific CTLs were induced in the patients after radiation therapy. The CTLs recognized cancer testis antigen derived peptides that were expressed on esophageal cancer cells. Furthermore, a role of the CTLs was also investigated. In mouse tumor models, a radiation therapy also induced tumor specific CTLs. The radiation therapy failed when CTLs were removed by using specific antibody, suggesting that anti-tumor immunity, such as the CTLs, was required for success of the therapy.
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